Title:
SYSTEMS AND METHODS FOR DIAGNOSTICS FOR BIOLOGICAL DISORDERS ASSOCIATED WITH PERIODIC VARIATIONS IN METAL METABOLISM
Document Type and Number:
WIPO Patent Application WO/2020/247781
Kind Code:
A8
Abstract:
A method for evaluating a subject for a biological condition associated with metal metabolism includes sampling positions along a biological sample of the subject to obtain several ion samples. Each ion sample corresponds to a position on the biological sample and each position represents an amount of growth of the biological sample. The obtained ions are analyzed with a mass spectrometer thereby obtaining a plurality of traces. Each such trace represents a concentration of a corresponding elemental isotope, in a plurality of elemental isotopes, over time. A set of features is derived from the traces. Each feature is determined by a variation of a single isotope or a combination of isotopes in the plurality of traces. The set of features is inputted into a trained classifier to obtain a probability that the subject has the biological condition associated with metal metabolism.
Inventors:
ARORA MANISH (US)
CURTIN PAUL (US)
AUSTIN CHRISTINE (US)
CURTIN PAUL (US)
AUSTIN CHRISTINE (US)
Application Number:
PCT/US2020/036368
Publication Date:
January 20, 2022
Filing Date:
June 05, 2020
Export Citation:
Assignee:
ICAHN SCHOOL MED MOUNT SINAI (US)
International Classes:
G01N23/223
Attorney, Agent or Firm:
LOVEJOY, Brett, A. et al. (US)
Download PDF: