Title:
SYSTEMS AND METHODS FOR INTELLIGENT GENOTYPING BY ALLELES COMBINATION DECONVOLUTION
Document Type and Number:
WIPO Patent Application WO/2023/129628
Kind Code:
A3
Abstract:
Methods and systems for improving computer efficiency by intelligently selecting subsets of possible short tandem repeat (STR) allele combinations for further deconvolution analysis are disclosed. In one embodiment, at each locus, for a currently analyzed contribution ratio scenario of a plurality of contribution ratio scenarios, a processor computes an adjusted evidence profile. For a first, or next, unidentified contributor having a pre-determined highest remaining contribution ratio in the currently analyzed contribution ratio scenario for the plurality of contributors, a processor computes a first range of expected peak heights using at least the pre-determined highest remaining contribution ratio, a selected degradation value, and a peak height ratio distribution. Also disclosed are methods and systems for intelligently estimating the number of contributors to a biological sample.
Inventors:
ROTH CHANTAL (US)
Application Number:
PCT/US2022/054204
Publication Date:
August 03, 2023
Filing Date:
December 28, 2022
Export Citation:
Assignee:
LIFE TECHNOLOGIES CORP (US)
International Classes:
G16B20/20; G16B40/10
Domestic Patent References:
| WO2019014455A2 | 2019-01-17 |
Foreign References:
| US20130173172A1 | 2013-07-04 |
Other References:
FREDERICK R. BIEBER ET AL: "Evaluation of forensic DNA mixture evidence: protocol for evaluation, interpretation, and statistical calculations using the combined probability of inclusion", BMC GENETICS, vol. 17, no. 1, 31 August 2016 (2016-08-31), XP055539573, DOI: 10.1186/s12863-016-0429-7
Attorney, Agent or Firm:
MAURIEL, Michael et al. (US)
Download PDF: