Title:
SYSTEMS AND METHODS FOR OPENING OBSTRUCTED BIOLOGICAL CONDUITS
Document Type and Number:
WIPO Patent Application WO2001021574
Kind Code:
A9
Abstract:
The invention provides methods to treating an obstructed biological conduit, that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes preventively dilating a section of conduit to minimize the risk of obstruction formation.
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Inventors:
FRANANO NICHOLAS F (US)
Application Number:
PCT/US2000/026237
Publication Date:
December 27, 2002
Filing Date:
September 24, 2000
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
FRANANO NICHOLAS F (US)
FRANANO NICHOLAS F (US)
International Classes:
A61M25/00; A61D7/00; A61K31/00; A61K31/167; A61K38/46; A61K38/48; A61K38/55; A61K45/00; A61K45/06; A61P1/16; A61P9/00; (IPC1-7): C07C69/76
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