Title:
SYSTEMS AND METHODS FOR TREATMENT OF ANDROGENETIC SKIN CONDITIONS BY MICROBIAL ORGANISMS
Document Type and Number:
WIPO Patent Application WO/2014/018549
Kind Code:
A3
Abstract:
A specific naturally occurring or genetically modified bacterial strain can be introduced into the hair follicle of patients suffering from androgenetic alopecia as to reduce the bioavailable extracellular testosterone and hence reduce the effect of androgens on the hair follicle.
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Inventors:
GOREN ANDY O (US)
MCCOY JOHN (US)
MCCOY JOHN (US)
Application Number:
PCT/US2013/051715
Publication Date:
April 10, 2014
Filing Date:
July 23, 2013
Export Citation:
Assignee:
APPLIED BIOLOGY INC (US)
International Classes:
A61Q7/00; A61K35/74; A61K35/744; A61P17/00; C12N1/21
Domestic Patent References:
| WO2011123396A1 | 2011-10-06 | |||
| WO2001003687A2 | 2001-01-18 | |||
| WO2012078649A1 | 2012-06-14 |
Foreign References:
| JP2004149422A | 2004-05-27 | |||
| US6242244B1 | 2001-06-05 | |||
| US20020187490A1 | 2002-12-12 | |||
| US20090136924A1 | 2009-05-28 | |||
| US20120129789A1 | 2012-05-24 | |||
| US20120077214A1 | 2012-03-29 |
Other References:
HORINOUCHI ET AL.: "A new bacterial steroid degradation gene cluster in Comamonas testosteroni TA441 which consists of aromatic-compound degradation genes for seco-steroids and 3-ketosteroid dehydrogenase genes.", APPL ENVIRON MICROBIOL, vol. 69, no. 8, August 2003 (2003-08-01), pages 4421 - 30
BOJAROVA ET AL.: "Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 12, no. 5, October 2008 (2008-10-01), pages 573 - 581
WHITING: "Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia.", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 28, 5, May 1993 (1993-05-01), pages 755 - 63
NIXON ET AL.: "Testosterone metabolism by isolated human axillary corynebacterium spp.: A gaschromatographic mass-spectrometric study.", JOURNAL OF STEROID BIOCHEMISTRY, vol. 24, no. ISSUE, April 1986 (1986-04-01), pages 887 - 892, Retrieved from the Internet [retrieved on 20140117]
BEZIRTZOGLOU: "intestinal cytochromes P450 regulating the intestinal microbiota and its probiotic profile", MICROBIAL ECOLOGY IN HEALTH & DISEASE, 7 September 2012 (2012-09-07), pages 1 - 10
GOODMAN ET AL.: "Biofilms can be dispersed by focusing the immune system on a common family of bacterial.", MUCOSA! TMMUNOI., vol. 4, no. 6, November 2011 (2011-11-01), pages 625 - 37
PHILIPP: "Bacterial degradation of bile salts", APPL MICROBIOL BIOTECHNOL., vol. 89, no. 4, February 2011 (2011-02-01), pages 903 - 15
ISMAIL ET AL.: "Oxic and Anoxic Metabolism of Steroids by Bacteria", J BIOREMED BIODEGRAD, 2011, pages 1 - 13
SWAIN: "Two novel transporters essential for reassimilation of cholic acid metabolites excreted by rhodococcus jostii rha1", A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE IN THE FACULTY OF GRADUATE STUDIES, August 2011 (2011-08-01), UNIVERSITY OF BRITISH COLUMBIA, Retrieved from the Internet [retrieved on 20140116]
BOJAROVA ET AL.: "Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 12, no. 5, October 2008 (2008-10-01), pages 573 - 581
WHITING: "Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia.", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 28, 5, May 1993 (1993-05-01), pages 755 - 63
NIXON ET AL.: "Testosterone metabolism by isolated human axillary corynebacterium spp.: A gaschromatographic mass-spectrometric study.", JOURNAL OF STEROID BIOCHEMISTRY, vol. 24, no. ISSUE, April 1986 (1986-04-01), pages 887 - 892, Retrieved from the Internet
BEZIRTZOGLOU: "intestinal cytochromes P450 regulating the intestinal microbiota and its probiotic profile", MICROBIAL ECOLOGY IN HEALTH & DISEASE, 7 September 2012 (2012-09-07), pages 1 - 10
GOODMAN ET AL.: "Biofilms can be dispersed by focusing the immune system on a common family of bacterial.", MUCOSA! TMMUNOI., vol. 4, no. 6, November 2011 (2011-11-01), pages 625 - 37
PHILIPP: "Bacterial degradation of bile salts", APPL MICROBIOL BIOTECHNOL., vol. 89, no. 4, February 2011 (2011-02-01), pages 903 - 15
ISMAIL ET AL.: "Oxic and Anoxic Metabolism of Steroids by Bacteria", J BIOREMED BIODEGRAD, 2011, pages 1 - 13
SWAIN: "Two novel transporters essential for reassimilation of cholic acid metabolites excreted by rhodococcus jostii rha1", A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE IN THE FACULTY OF GRADUATE STUDIES, August 2011 (2011-08-01), UNIVERSITY OF BRITISH COLUMBIA, Retrieved from the Internet
Attorney, Agent or Firm:
OGDEN, Christopher, L. et al. (Palo Alto, California, US)
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