Title:
T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/138488
Kind Code:
A3
Abstract:
This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Thl7 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
Inventors:
REGEV AVIV (US)
KUCHROO VIJAY K (US)
GAUBLOMME JELLERT (BE)
LEE YOUJIN (US)
WANG CHAO (US)
YOSEF NIR (US)
PARK HONGKUN (US)
KAMINSKI JAMES (US)
KUCHROO VIJAY K (US)
GAUBLOMME JELLERT (BE)
LEE YOUJIN (US)
WANG CHAO (US)
YOSEF NIR (US)
PARK HONGKUN (US)
KAMINSKI JAMES (US)
Application Number:
PCT/US2016/019949
Publication Date:
November 03, 2016
Filing Date:
February 26, 2016
Export Citation:
Assignee:
BROAD INST INC (US)
MASSACHUSETTS INST TECHNOLOGY (US)
HARVARD COLLEGE (US)
BRIGHAM & WOMENS HOSPITAL INC (US)
UNIV CALIFORNIA (US)
MASSACHUSETTS INST TECHNOLOGY (US)
HARVARD COLLEGE (US)
BRIGHAM & WOMENS HOSPITAL INC (US)
UNIV CALIFORNIA (US)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2014134351A2 | 2014-09-04 |
Foreign References:
| EP2264182A1 | 2010-12-22 |
Other References:
GAUBLOMME JELLERT T ET AL: "Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity", CELL, vol. 163, no. 6, 19 November 2015 (2015-11-19), pages 1400 - 1412, XP029333007, ISSN: 0092-8674, DOI: 10.1016/J.CELL.2015.11.009
NIR YOSEF ET AL: "Dynamic regulatory network controlling TH17 cell differentiation", NATURE, vol. 496, no. 7446, 6 March 2013 (2013-03-06), pages 461 - 468, XP055112825, ISSN: 0028-0836, DOI: 10.1038/nature11981
NIR YOSEF ET AL: "Dynamic regulatory network controlling TH17 cell differentiation: Supplementary information", NATURE, vol. 496, no. 7446, 6 March 2013 (2013-03-06), pages 461 - 468, XP055190193, ISSN: 0028-0836, DOI: 10.1038/nature11981
YOUJIN LEE ET AL: "Induction and molecular signature of pathogenic TH17 cells", NATURE IMMUNOLOGY, vol. 13, no. 10, 9 September 2012 (2012-09-09), pages 991 - 999, XP055190404, ISSN: 1529-2908, DOI: 10.1038/ni.2416
TOSHIMASA ARANAMI ET AL: "Th17 Cells and Autoimmune Encephalomyelitis (EAE/MS)", ALLERGOLOGY INTERNATIONAL, vol. 57, no. 2, 1 January 2008 (2008-01-01), JP, pages 115 - 120, XP055282946, ISSN: 1323-8930, DOI: 10.2332/allergolint.R-07-159
FURUZAWA-CARBALLEDA ET AL: "Autoimmune inflammation from the Th17 perspective", AUTOIMMUNITY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 6, no. 3, 5 February 2007 (2007-02-05), pages 169 - 175, XP005876578, ISSN: 1568-9972, DOI: 10.1016/J.AUTREV.2006.10.002
NIR YOSEF ET AL: "Dynamic regulatory network controlling TH17 cell differentiation", NATURE, vol. 496, no. 7446, 6 March 2013 (2013-03-06), pages 461 - 468, XP055112825, ISSN: 0028-0836, DOI: 10.1038/nature11981
NIR YOSEF ET AL: "Dynamic regulatory network controlling TH17 cell differentiation: Supplementary information", NATURE, vol. 496, no. 7446, 6 March 2013 (2013-03-06), pages 461 - 468, XP055190193, ISSN: 0028-0836, DOI: 10.1038/nature11981
YOUJIN LEE ET AL: "Induction and molecular signature of pathogenic TH17 cells", NATURE IMMUNOLOGY, vol. 13, no. 10, 9 September 2012 (2012-09-09), pages 991 - 999, XP055190404, ISSN: 1529-2908, DOI: 10.1038/ni.2416
TOSHIMASA ARANAMI ET AL: "Th17 Cells and Autoimmune Encephalomyelitis (EAE/MS)", ALLERGOLOGY INTERNATIONAL, vol. 57, no. 2, 1 January 2008 (2008-01-01), JP, pages 115 - 120, XP055282946, ISSN: 1323-8930, DOI: 10.2332/allergolint.R-07-159
FURUZAWA-CARBALLEDA ET AL: "Autoimmune inflammation from the Th17 perspective", AUTOIMMUNITY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 6, no. 3, 5 February 2007 (2007-02-05), pages 169 - 175, XP005876578, ISSN: 1568-9972, DOI: 10.1016/J.AUTREV.2006.10.002
Attorney, Agent or Firm:
KOWALSKI, Thomas, J. et al. (1633 BroadwayNew York, NY, US)
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