Title:
T CELL RECEPTOR FOR RECOGNIZING SAGE1 ANTIGEN SHORT-CHAIN POLYPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2018/077242
Kind Code:
A1
Abstract:
Provided is are a T cell receptor (TCR) capable of specific binding of short-chain polypeptide VFSTVPPAFI derived from a SAGE1 antigen, a nucleic acid molecule coding the TCR, a vector comprising the nucleic acid molecule, and a cell transducing the TCR. The antigen short-chain polypeptide VFSTVPPAFI can form a complex with HLA A2402 and be transduced together to cell surface.
Inventors:
LI YI (CN)
CHEN AN'AN (CN)
CHEN AN'AN (CN)
Application Number:
PCT/CN2017/108081
Publication Date:
May 03, 2018
Filing Date:
October 27, 2017
Export Citation:
Assignee:
GUANGZHOU INST BIOMED & HEALTH (CN)
International Classes:
C07K14/725; A61K38/17; A61P35/00; A61P37/02; C12N5/10; C12N15/12; C12N15/867
Domestic Patent References:
| WO2014206304A1 | 2014-12-31 |
Foreign References:
| EP2048159A1 | 2009-04-15 | |||
| US20080292602A1 | 2008-11-27 | |||
| CN101155829A | 2008-04-02 |
Other References:
MARTELANGE V.: "Identification on a Human Sarcoma of Two New Genes with Tumor-specific Expression", CANCER RESEARCH, vol. 60, 15 July 2000 (2000-07-15), pages 14, XP002256958, ISSN: 0008-5472
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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