THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF

WIPO Patent Application WO/2017/217439

A1

The purpose of the invention is to provide a compound that inhibits the binding of the ALS-related mutant SOD1 and Derlin-1, a drug containing the compound, and a method for treating ALS by administering the drug to a patient. More specifically, the compound is represented by general formula (1). [In formula (1), X represents a sulfur atom or -CH=CH-, A1-A4 each independently are a carbon atom or nitrogen atom and at least one of A1-A4 is a nitrogen atom, R1 is a 1,2,3,4-tetrahydroquinolyl group (or 3,4-dihydro-1(2H-quinolyl group), 3,4-dihydro-4,4-dimethyl-1(2H)-quinolyl group, 2,3,4,5-tetrahydro-1H-1-benzazepinyl group, or substituent represented by formula (2) (in formula (2), R4 is an unsubstituted or optionally substituted phenyl group, unsubstituted or optionally substituted pyridyl group, or unsubstituted or optionally substituted naphthyl group, R5 is a hydrogen atom, lower alkyl group, lower alkenyl group, lower alkynyl group (optionally including an oxygen atom and/or double bond), or an unsubstituted or optionally substituted aromatic lower alkyl group), R2 represents a hydrogen atom, lower alkyl group, lower acyl group, or an unsubstituted or optionally substituted aromatic lower alkyl group, R3 represents a hydrogen atom, or R2 and R3 may bond to each other to form a ring.]

WO/2014/060908	IMPROVED PROCESS FOR PREPARATION OF REVAPRAZAN HYDROCHLORIDE
WO/2002/088107	NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF
JP3755195	METALLIC COMPLEX COLORING MATTER, HEAT-SENSITIVE TRANSFER IMAGE-FORMING MATERIAL, FORMATION OF IMAGE AND FORMATION OF HEAT-SENSITIVE TRANSFER IMAGE

ICHIJO HIDENORI (JP)
HOMMA KENGO (JP)
TSUBURAYA NAOMI (JP)
NAGANO TETSUO (JP)
OKABE TAKAYOSHI (JP)
KOJIMA HIROTATSU (JP)
SHIMONISHI MANABU (JP)
FUJISAWA TAKAO (JP)
SHIBATA NORIO (JP)
HIGUCHI TSUNEHIKO (JP)
NAKAMURA SEIICHI (JP)
NAKAGAWA HIDEHIKO (JP)
IKEDA SHIN-ICHI (JP)

PCT/JP2017/021895

December 21, 2017

June 14, 2017

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UNIV TOKYO (JP)
UNIV NAGOYA CITY PUBLIC UNIV CORP (JP)

C07D401/04; A61K31/4365; A61P21/02; C07D495/04

WO2014207213A1	2014-12-31
WO2014089378A1	2014-06-12
WO2013033037A2	2013-03-07
WO2011006158A2	2011-01-13
WO2010151799A2	2010-12-29
WO2008011560A2	2008-01-24

JP2007151478A

2007-06-21

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OKUHARA Koji et al. (JP)

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