Title:
TYROSINE DERIVATIVES SUBSTITUTED BYALKANOYLAS hPPAR&agr & hPPAR&gammad ANGONISTS
Document Type and Number:
WIPO Patent Application WO/2005/116018
Kind Code:
A1
Abstract:
The invention provides compounds of the general formula (I), racemic mixtures, optical isomers, pharmaceutically acceptable salts, solvates and pharmaceutical compositions thereof. The definitions of substituents in the general formula (I) are the same as the definitions of claims. The present invention also relates to the preparation for the compounds of the general formula (I) and the usage thereof for the preparation of a medicament, which is used for treating hyperglycemia, lipidosis lipaemia and NIDDM (type II) diabetes including diabetes involving lipidosis lipaemia.
Inventors:
LI SONG (CN)
ZHOU XINBO (CN)
WANG LILI (CN)
XU CHENG (CN)
RUAN CHENGMAI (CN)
LIN CUIFANG (CN)
XIAO JUNHAI (CN)
ZHENG ZHIBING (CN)
LIU HONGYING (CN)
XIE YUNDE (CN)
ZHONG WU (CN)
CUI HAO (CN)
ZHOU XINBO (CN)
WANG LILI (CN)
XU CHENG (CN)
RUAN CHENGMAI (CN)
LIN CUIFANG (CN)
XIAO JUNHAI (CN)
ZHENG ZHIBING (CN)
LIU HONGYING (CN)
XIE YUNDE (CN)
ZHONG WU (CN)
CUI HAO (CN)
Application Number:
PCT/CN2005/000148
Publication Date:
December 08, 2005
Filing Date:
February 02, 2005
Export Citation:
Assignee:
INST PHARM & TOXICOLOGY AMMS (CN)
LI SONG (CN)
ZHOU XINBO (CN)
WANG LILI (CN)
XU CHENG (CN)
RUAN CHENGMAI (CN)
LIN CUIFANG (CN)
XIAO JUNHAI (CN)
ZHENG ZHIBING (CN)
LIU HONGYING (CN)
XIE YUNDE (CN)
ZHONG WU (CN)
CUI HAO (CN)
LI SONG (CN)
ZHOU XINBO (CN)
WANG LILI (CN)
XU CHENG (CN)
RUAN CHENGMAI (CN)
LIN CUIFANG (CN)
XIAO JUNHAI (CN)
ZHENG ZHIBING (CN)
LIU HONGYING (CN)
XIE YUNDE (CN)
ZHONG WU (CN)
CUI HAO (CN)
International Classes:
A61K31/421; A61K31/496; A61P3/00; C07D263/32; C07D401/12; C07D413/12; (IPC1-7): C07D413/12; C07D401/12; A61K31/421; A61K31/496; A61P3/00
Domestic Patent References:
| WO2003066574A1 | 2003-08-14 | |||
| WO2004067495A1 | 2004-08-12 | |||
| WO2003059895A1 | 2003-07-24 |
Foreign References:
| US6194446B1 | 2001-02-27 | |||
| JP2000344748A | 2000-12-12 | |||
| US6506781B1 | 2003-01-14 | |||
| CN1321152A | 2001-11-07 |
Other References:
REYNOLDS D.J. AND HERMITAGE S.A.: "The synthesis of GW710936X to support the development of L-tyrosine-based PPARgamma Agonists with Reduced Molecular Weight", TETRAHEDRON, vol. 57, 2001, pages 7765 - 7770
LIU K.G. ET AL: "Synthesis and Biological Activity of L-Tyrsine-based PPARgamma Agonists With Reduced Molecular Weight", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, 2001, pages 3111 - 3113
YI X. AND GUO Z-R.: "Study on 3D-qsar of PPARgamma Agonists with Thiazolidinedione and Arylketo-Acid Moieties", ACTA PHARMACEUTICA SINICA (CHINA), vol. 36, no. 4, 2001, pages 262 - 268
CAI Z-F. AND GUO Z-R.: "Peroxisome proleferator-activates receptors and their modulators", ACTA PHARMACEUTICA SINICA (CHINA), vol. 39, no. 2, 2004, pages 158 - 160
CHENG F. ET AL: "Research progress in PPARgamma agonists", CHINESE JOURNAL OLF MEDICINAL CHEMISTRY, vol. 13, no. 2, April 2003 (2003-04-01), pages 110
LIU K.G. ET AL: "Synthesis and Biological Activity of L-Tyrsine-based PPARgamma Agonists With Reduced Molecular Weight", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, 2001, pages 3111 - 3113
YI X. AND GUO Z-R.: "Study on 3D-qsar of PPARgamma Agonists with Thiazolidinedione and Arylketo-Acid Moieties", ACTA PHARMACEUTICA SINICA (CHINA), vol. 36, no. 4, 2001, pages 262 - 268
CAI Z-F. AND GUO Z-R.: "Peroxisome proleferator-activates receptors and their modulators", ACTA PHARMACEUTICA SINICA (CHINA), vol. 39, no. 2, 2004, pages 158 - 160
CHENG F. ET AL: "Research progress in PPARgamma agonists", CHINESE JOURNAL OLF MEDICINAL CHEMISTRY, vol. 13, no. 2, April 2003 (2003-04-01), pages 110
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (Vantone New World Plaza 2 Fuchengmenwai Street, Beijing 7, CN)
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