Title:
TABLET COMPRISING AN ESOMEPRAZOLE SALT HAVING IMPROVED CHEMICAL STABILITY
Document Type and Number:
WIPO Patent Application WO/2018/110683
Kind Code:
A1
Abstract:
The present invention provides a technical means (preferably an easy-to-use means) for producing a tablet in which properties of an esomeprazole salt, such as chemical stability, are improved. Provided is an uncoated tablet in which the moisture absorption rate is kept low and which contains a metal salt of esomeprazole and a low-hygroscopic additive in an amount of at least 80.0 wt% with respect to the total weight of the uncoated tablet, wherein the additive preferably comprises one or two types of excipients, one or two types of disintegrants, one or two types of binding agents, and one or two types of lubricants. Examples of the low-hygroscopic additive include lactose hydrate, anhydrous lactose, D-mannitol, xylitol, D-sorbitol, maltitol, maltose, sucrose, reduced maltose starch syrup, etc.
Inventors:
TANIGUCHI TOSHIYA (JP)
Application Number:
PCT/JP2017/045018
Publication Date:
June 21, 2018
Filing Date:
December 15, 2017
Export Citation:
Assignee:
OHARA PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/4439; A61K9/20; A61K9/28; A61K47/26; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61P1/04
Foreign References:
| JP2008519070A | 2008-06-05 | |||
| JP2007524646A | 2007-08-30 |
Other References:
SAGAWA, YOSHIHISA: "tableting and powder control technology", PHARMACEUTICAL MANUFACTURING TECHNOLOGY: PULVERIZATION, MIXING, GRANULATION, DRYING, pages 207 - 209
Attorney, Agent or Firm:
YAMAMOTO Shusaku et al. (JP)
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