Title:
TABLET AND METHOD FOR MANUFACTURING SAME
Document Type and Number:
WIPO Patent Application WO/2022/004871
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a tablet that includes a high concentration of acetaminophen, that elutes acetaminophen at a rate of at least 80% in fifteen minutes, and that can be manufactured by dry tableting. The present invention provides a tablet, containing acetaminophen with a median grain diameter in the range 100–350 μm, crystalline cellulose with a bulk density in the range 0.10–0.23 g/cm3, and disintegrants of at least two types, wherein: the disintegrants of at least two types are a disintegrant (a) of at least one type selected from the group consisting of crospovidone, croscarmellose sodium, and sodium starch glycolate, and a disintegrant (b) that is low-substituted hydroxypropylcellulose; and the acetaminophen content per tablet is at least 86% by weight.
Inventors:
YAMASHITA MIKI (JP)
TAKIGAMI YUSUKE (JP)
TAKIGAMI YUSUKE (JP)
Application Number:
PCT/JP2021/025101
Publication Date:
January 06, 2022
Filing Date:
July 02, 2021
Export Citation:
Assignee:
AYUMI PHARMACEUTICAL CORP (JP)
International Classes:
A61K31/167; A61K9/20; A61K47/32; A61K47/36; A61K47/38; A61P29/00
Domestic Patent References:
| WO2019093434A1 | 2019-05-16 |
Foreign References:
| JP2013216610A | 2013-10-24 | |||
| JP2017210478A | 2017-11-30 | |||
| JP2018058910A | 2018-04-12 |
Attorney, Agent or Firm:
SIKS & CO. (JP)
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