Title:
TARGET AND ASSAY FOR LEAD COMPOUNDS FOR POLYCYSTIC KIDNEY DISEASE
Document Type and Number:
WIPO Patent Application WO2007021628
Kind Code:
A9
Abstract:
Described herein are therapeutic strategies (methods and compositions) useful for treating conditions in which cilia are affected and which manifest with cysts and/or fibrosis, such as conditions in which the kidney, pancreas, liver and/or spleen are affected and contain cysts. Particular embodiments described herein are therapeutic strategies in which PC-2 agonists, particularly agonists (calcium channel agonists) that target PC-2 directly and/or selectively, are administered to individuals with mutations in PKDl, in order to alter the course of polycystic kidney disease, particularly ADPKD.
Inventors:
SOMLO STEFAN (US)
CREWS CRAIG M (US)
QUINN STEPHANIE J (US)
CREWS CRAIG M (US)
QUINN STEPHANIE J (US)
Application Number:
PCT/US2006/030671
Publication Date:
May 03, 2007
Filing Date:
August 09, 2006
Export Citation:
Assignee:
UNIV YALE (US)
SOMLO STEFAN (US)
CREWS CRAIG M (US)
QUINN STEPHANIE J (US)
SOMLO STEFAN (US)
CREWS CRAIG M (US)
QUINN STEPHANIE J (US)
International Classes:
G01N33/50
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