Title:
TARGET DIRECTIONAL CARRIER
Document Type and Number:
WIPO Patent Application WO/2005/079859
Kind Code:
A1
Abstract:
A target directional carrier capable of delivering any desired drug (for example, physiologically active peptide or gene coding for the same) selectively to target cells or tissue within a living body. In particular, there is provided a target directional carrier comprising a polypeptide having MAM domain or having the same in part thereof, or a nucleic acid having a gene coding for the polypeptide having MAM domain or having the same in part thereof, which target directional carrier is adapted to bind any desired drug to thereby achieve delivery of the drug to target tissue. There is further provided a target directional drug complex comprised of the target directional carrier having a drug to be delivered to target tissue bound thereto.
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Inventors:
SEKIGUCHI KIYOTOSHI (JP)
SATO YUYA (JP)
SATO YUYA (JP)
Application Number:
PCT/JP2004/012663
Publication Date:
September 01, 2005
Filing Date:
August 25, 2004
Export Citation:
Assignee:
UNIV OSAKA (JP)
SEKIGUCHI KIYOTOSHI (JP)
SATO YUYA (JP)
SEKIGUCHI KIYOTOSHI (JP)
SATO YUYA (JP)
International Classes:
A61K47/48; A61K48/00; C07K14/47; C12N15/12; (IPC1-7): A61K47/48; C07K14/47; C12N15/12
Foreign References:
| JPH0334996A | 1991-02-14 |
Other References:
SHEN P. ET AL: "Expression of a truncated receptor protein tyrosine phosphatase kappa in the brain of an adult transgenic mouse.", BRAIN RESEARCH., vol. 826, 1999, pages 157 - 171, XP002990295
BRANDENBERGER R. ET AL: "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8 beta1 in the embryonic kidney.", JOURNAL OF CELL BIOLOGY., vol. 154, 2001, pages 447 - 458, XP002290098
SATO Y. ET AL: "Nephronectin binds to laminin-10 through its MAM domain.", SEIKAGAKU., vol. 75, no. 8, 2003, pages 1120, XP002990296
SATO Y. ET AL: "Shinki Kiteimaku Tanpakushitsu nephronectin no Kino Kaiseki.", OSAKA DAIGAKU RIGAKU KENKYUKA HAKASE ZENKI KATEI GYOSEKI HAPPYOKAI YOSHISHU., 2003, pages 47, XP002990297
YEUNG G. ET AL: "Cloning of a novel epidermal growth factor repeat containing gene EGFL6: Expressed in tumor and fetal tissues.", GENOMICS., vol. 62, 1999, pages 304 - 307, XP004444737
BRANDENBERGER R. ET AL: "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8 beta1 in the embryonic kidney.", JOURNAL OF CELL BIOLOGY., vol. 154, 2001, pages 447 - 458, XP002290098
SATO Y. ET AL: "Nephronectin binds to laminin-10 through its MAM domain.", SEIKAGAKU., vol. 75, no. 8, 2003, pages 1120, XP002990296
SATO Y. ET AL: "Shinki Kiteimaku Tanpakushitsu nephronectin no Kino Kaiseki.", OSAKA DAIGAKU RIGAKU KENKYUKA HAKASE ZENKI KATEI GYOSEKI HAPPYOKAI YOSHISHU., 2003, pages 47, XP002990297
YEUNG G. ET AL: "Cloning of a novel epidermal growth factor repeat containing gene EGFL6: Expressed in tumor and fetal tissues.", GENOMICS., vol. 62, 1999, pages 304 - 307, XP004444737
Attorney, Agent or Firm:
Saegusa, Eiji (1-7-1 Doshomachi, Chuo-k, Osaka-shi Osaka 45, JP)
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