Title:
TARGET FOR DRUG TREATMENT OF TUMOR METASTASIS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/184306
Kind Code:
A1
Abstract:
Disclosed is a use of PRAK as a drug target in screening a drug for inhibiting or preventing tumor cell metastasis. Based on the discovery that PRAK can be used as a target for tumor cell metastasis, further provided is a drug capable of inhibiting or preventing tumor cell metastasis. The active ingredient of the drug can reduce the expression level of PRAK or inhibit the bioactivity of PRAK, and the inhibition or prevention of tumor cell metastasis can be achieved by regulating the cell migration and the expression and/or function of HIF1α, MMP2 and/or EMT series molecules.
Inventors:
ZHANG YU (CN)
WANG WEI (CN)
WANG YUQING (CN)
WANG WEI (CN)
WANG YUQING (CN)
Application Number:
PCT/CN2018/110767
Publication Date:
October 03, 2019
Filing Date:
October 18, 2018
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
A61K31/5377; A61P35/04; A61P35/00
Domestic Patent References:
| WO2007133352A2 | 2007-11-22 |
Foreign References:
| CN101454326A | 2009-06-10 | |||
| CN102036997A | 2011-04-27 | |||
| CN103540655A | 2014-01-29 | |||
| CN101454326A | 2009-06-10 | |||
| CN102036997A | 2011-04-27 |
Other References:
YOSHIZUKA N.: "A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis", MOLECULAR AND CELLULAR BIOLOGY, vol. 32, no. 3, February 2012 (2012-02-01), pages 606 - 618, XP055639050
AL-MAHDI R., ET AL.: "A novel role for atypical MAPK kinase ERK3 in regulating breast cancer cell morphology and migration", CELL ADHESION & MIGRATION, vol. 9, no. 6, 31 December 2015 (2015-12-31), pages 483 - 494, XP055639055
GAESTEL M.: "MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 3, 8 January 2016 (2016-01-08), XP055639069
ZHENG M.: "Rheb phosphorylation is involved in p38-regulated/activated protein kinase-mediated tumor suppression in liver cancer", ONCOLOGY LETTERS, vol. 10, no. 3, September 2015 (2015-09-01), pages 1655 - 1661, XP055639083
AL-MAHDI R., ET AL.: "A novel role for atypical MAPK kinase ERK3 in regulating breast cancer cell morphology and migration", CELL ADHESION & MIGRATION, vol. 9, no. 6, 31 December 2015 (2015-12-31), pages 483 - 494, XP055639055
GAESTEL M.: "MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 3, 8 January 2016 (2016-01-08), XP055639069
ZHENG M.: "Rheb phosphorylation is involved in p38-regulated/activated protein kinase-mediated tumor suppression in liver cancer", ONCOLOGY LETTERS, vol. 10, no. 3, September 2015 (2015-09-01), pages 1655 - 1661, XP055639083
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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