Title:
TARGET MOLECULE REDUCTION METHOD, REDUCTION DEVICE, AND ELECTRODE
Document Type and Number:
WIPO Patent Application WO/2024/005059
Kind Code:
A1
Abstract:
This target molecule reduction method includes: a first step for reducing disulfide bonds in target molecules present in a reaction system with a thioredoxin whose state changes between oxidized and reduced forms and that is in the reduced form; and a second step for reducing the thioredoxin whose state has changed to the oxidized form by being oxidized by the disulfide bonds in the first step, by donating electrons from an electrode connected to an external power source outside the reaction system, and thereby changing the state of the oxidized-form thioredoxin to the reduced form. The thioredoxin is immobilized on the surface of the electrode directly or via a linker, and the first and second steps are carried out in a condition in which the reaction system is basic.
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Inventors:
WAYAMA FUMIYA
TSUJI KIYOTAKA
HATSUGAI NORIYUKI
TSUJI KIYOTAKA
HATSUGAI NORIYUKI
Application Number:
PCT/JP2023/023939
Publication Date:
January 04, 2024
Filing Date:
June 28, 2023
Export Citation:
Assignee:
PANASONIC IP MAN CO LTD (JP)
International Classes:
C25B3/25; C12M1/40; C25B3/05; C25B3/09; C25B9/00; C25B11/02; C25B11/04; C12N9/02; C12N11/14
Foreign References:
| US20170113951A1 | 2017-04-27 | |||
| JP2011162838A | 2011-08-25 | |||
| JPS372022B1 | 1962-05-16 | |||
| JP2004187625A | 2004-07-08 |
Attorney, Agent or Firm:
NII, Hiromori et al. (JP)
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