Title:
TARGETED DISRUPTION OF THE MHC CELL RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2017/106537
Kind Code:
A3
Abstract:
Disclosed herein are methods and compositions for inactivating MHC genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
Inventors:
LEE GARY K (US)
PASCHON DAVID (US)
ZHANG LEI (US)
PASCHON DAVID (US)
ZHANG LEI (US)
Application Number:
PCT/US2016/066988
Publication Date:
July 27, 2017
Filing Date:
December 15, 2016
Export Citation:
Assignee:
SANGAMO BIOSCIENCES INC (US)
International Classes:
C07K14/74; C07K14/725; C12N5/0783; C12N5/10; C12N5/12; C12N15/09
Domestic Patent References:
| WO2015136001A1 | 2015-09-17 | |||
| WO2007127999A2 | 2007-11-08 | |||
| WO2011012691A2 | 2011-02-03 |
Foreign References:
| US20140093913A1 | 2014-04-03 | |||
| US20050064474A1 | 2005-03-24 | |||
| US20150128309A1 | 2015-05-07 |
Other References:
See also references of EP 3390437A4
Attorney, Agent or Firm:
PASTERNAK, Dahna (US)
Download PDF:
Previous Patent: ACCUMULATOR MANAGEMENT
Next Patent: OFF-ROAD VEHICLE TIRE REPAIR PATCH, KIT AND METHOD
Next Patent: OFF-ROAD VEHICLE TIRE REPAIR PATCH, KIT AND METHOD