TARGETED AND LOCALIZED IN VIVO DELIVERY OF OLIGONUCLEOTIDES

Title:

TARGETED AND LOCALIZED IN VIVO DELIVERY OF OLIGONUCLEOTIDES

Document Type and Number:

WIPO Patent Application WO/2021/142454

Kind Code:

A1

Abstract:

This disclosure provides compositions and methods for the targeted and localized in vivo delivery of oligonucleotides. Compositions containing targeted oligonucleotide-HES conjugates are provided as are methods of making and using the conjugates in therapeutic, diagnostic, and other applications. The oligonucleotide-HES complexes contained in the targeted oligonucleotide-HES conjugates can cross membranes in a receptor-independent manner and can deliver oligonucleotides to complementary sequences in the cytosol of live cells in vivo. The targeted oligonucleotide-HES conjugates have uses that include the targeted and/or localized delivery of antisense oligonucleotides, siRNAs, shRNAs, Dicer substrates, miRNAs, anti-miRNA, and other nucleic acid sequence in a living organism.

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Inventors:

PACKARD BEVERLY (US)
KOMORIYA AKIRA (US)

Application Number:

PCT/US2021/012988

Publication Date:

July 15, 2021

Filing Date:

January 11, 2021

Export Citation:

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Assignee:

ONCOLMMUNIN INC (US)

International Classes:

A61K31/713; A61K31/7088

Foreign References:

US20160040161A1	2016-02-11
US20130344508A1	2013-12-26

Attorney, Agent or Firm:

HOOVER, Kenley, K. (US)

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