Title:
TARGETED PHOTOTHERMAL BLACK PHOSPHORUS NANO PREPARATION AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/095017
Kind Code:
A1
Abstract:
A targeted photothermal black phosphorus nano preparation, comprising: a black phosphorus nano sheet, a polyethylene glycol adsorbed onto a surface of the black phosphorus nano sheet by electrostatic attraction, and a folic acid linked to the polyethylene glycol by an amide bond. One end of the polyethylene glycol is an amino group, and the other end is an imino group. A nitrogen atom of the imino group is linked to a carbonyl carbon atom of the folic acid to form the amide bond. The folic acid is disposed at an outermost layer of the nano preparation. Also disclosed is a preparation method of the targeted photothermal black phosphorus nano preparation and an application thereof for preparing a drug that treats cancer with targeted photothermal treatment at cellular levels.
Inventors:
ZHANG HAN (CN)
TAO WEI (CN)
ZHANG JIAYI (CN)
TAO WEI (CN)
ZHANG JIAYI (CN)
Application Number:
PCT/CN2017/088021
Publication Date:
May 31, 2018
Filing Date:
June 13, 2017
Export Citation:
Assignee:
UNIV SHENZHEN (CN)
International Classes:
A61K41/00; A61K47/60; A61P35/00
Foreign References:
| CN106620699A | 2017-05-10 |
Other References:
WEI TAO ET AL.: "Black Phosphorus: Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics ", ADVANCED MATERIALS, vol. 29, no. 1, 1603276, 2 January 2017 (2017-01-02), pages 1 - 9, XP055629753, ISSN: 1521-4095, DOI: 10.1002/adma.201603276
J.H. VAN STEENIS ET AL: "Preparation and characterization of Folate-Targeted pEG-coated pDMAEMA-based Polyplexes", JOURNAL OF CONTROLLED RELEASE, vol. 87, no. 1-3, pages 167 - 176, XP004412740, ISSN: 0168-3659, DOI: 10.1016/S0168-3659(02)00361-9
J.H. VAN STEENIS ET AL: "Preparation and characterization of Folate-Targeted pEG-coated pDMAEMA-based Polyplexes", JOURNAL OF CONTROLLED RELEASE, vol. 87, no. 1-3, pages 167 - 176, XP004412740, ISSN: 0168-3659, DOI: 10.1016/S0168-3659(02)00361-9
Attorney, Agent or Firm:
SCIHEAD IP LAW FIRM (CN)
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