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Title:
TARGETED UBIQUITINATION DEGRADATION BRD4 PROTEIN COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/156017
Kind Code:
A1
Abstract:
The present invention relates to a compound represented by formula (I) or a tautomer, optical isomer, deuterated substance, oxynitride, solvate, pharmaceutically acceptable salt or prodrug thereof, a preparation method for the compound, a pharmaceutical composition containing same and a use of the compound or the pharmaceutical composition in the preparation of a drug for the prevention and/or treatment of cancer, tumors, viral infections, depression, neurological disorders, trauma, age-related cataracts, organ transplant rejection or autoimmune diseases.

Inventors:
ZHAO CHUANWU (CN)
JIANG CHUNHUA (CN)
ZHANG YAN (CN)
ZHANG XUEJIAO (CN)
YANG JINLU (CN)
KANG JIEQIONG (CN)
ZHAO PEIPEI (CN)
Application Number:
PCT/CN2020/000027
Publication Date:
August 06, 2020
Filing Date:
February 03, 2020
Export Citation:
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Assignee:
CSPC ZHONGQI PHARMACEUTICAL TECH (SHIJIAZHUANG) CO LTD (CN)
International Classes:
A61P35/00; A61K47/55; A61K47/62; A61K47/66; A61P25/00; C07D471/04; C07D471/14; C07D475/00; C07D487/04; C07D495/04; C07D495/14
Domestic Patent References:
WO2017024317A22017-02-09
Foreign References:
CN107257800A2017-10-17
CN106458993A2017-02-22
US9809603B12017-11-07
CN108350062A2018-07-31
CN108136044A2018-06-08
CN106905347A2017-06-30
Other References:
JOURNAL OF BIOSCIENCES, vol. 41, no. 2, 2016, pages 295
ANGEW CHEM INT ED ENGL., vol. 55, 2016, pages 1966
See also references of EP 3919127A4
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