Title:
TARGETING CONJUGATES COMPRISING EFFECTOR MOLECULES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/178751
Kind Code:
A1
Abstract:
Provided are targeting conjugates comprising a targeting moiety and an effector molecule, wherein the effector molecule is conjugated to the targeting moiety via a conjugation site, wherein the effector molecule can be released from the targeting conjugate via cleavage. Also provided are compositions and methods of treatment or diagnosis using the targeting conjugates.
Inventors:
XIANG JUN (CN)
GAO WENLONG (CN)
GAO WENLONG (CN)
Application Number:
PCT/CN2021/077864
Publication Date:
September 01, 2022
Filing Date:
February 25, 2021
Export Citation:
Assignee:
SHANGHAI ALLYGEN BIOLOGICS CO LTD (CN)
International Classes:
A61K47/66; A61K39/385; A61K39/395; A61P35/00
Domestic Patent References:
| WO2001095942A2 | 2001-12-20 | |||
| WO2018237335A1 | 2018-12-27 | |||
| WO2017040344A2 | 2017-03-09 |
Foreign References:
| CN107952080A | 2018-04-24 |
Other References:
YING XU, SHIJIE JIN, WENBIN ZHAO, WENHUI LIU, DING DING, JIE ZHOU, SHUQING CHEN: "A Versatile Chemo-Enzymatic Conjugation Approach Yields Homogeneous and Highly Potent Antibody-Drug Conjugates", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 18, no. 11, 1 November 2017 (2017-11-01), Basel, CH , pages 2284, XP055709824, ISSN: 1661-6596, DOI: 10.3390/ijms18112284
R. M. SHARKEY, S. V. GOVINDAN, T. M. CARDILLO, D. M. GOLDENBERG: "Epratuzumab-SN-38: A New Antibody-Drug Conjugate for the Therapy of Hematologic Malignancies", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, INC., vol. 11, no. 1, 1 January 2012 (2012-01-01), pages 224 - 234, XP055125141, ISSN: 15357163, DOI: 10.1158/1535-7163.MCT-11-0632
LI QIYU, LI WENJING, XU KEYUAN, XING YUTONG, SHI HAOBO, JING ZHE, LI SHUANG, HONG ZHANGYONG: "PEG Linker Improves Antitumor Efficacy and Safety of Affibody-Based Drug Conjugates", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 4, 1 January 2021 (2021-01-01), pages 1540 - 86, XP055961521, DOI: 10.3390/ijms22041540
R. M. SHARKEY, S. V. GOVINDAN, T. M. CARDILLO, D. M. GOLDENBERG: "Epratuzumab-SN-38: A New Antibody-Drug Conjugate for the Therapy of Hematologic Malignancies", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, INC., vol. 11, no. 1, 1 January 2012 (2012-01-01), pages 224 - 234, XP055125141, ISSN: 15357163, DOI: 10.1158/1535-7163.MCT-11-0632
LI QIYU, LI WENJING, XU KEYUAN, XING YUTONG, SHI HAOBO, JING ZHE, LI SHUANG, HONG ZHANGYONG: "PEG Linker Improves Antitumor Efficacy and Safety of Affibody-Based Drug Conjugates", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 4, 1 January 2021 (2021-01-01), pages 1540 - 86, XP055961521, DOI: 10.3390/ijms22041540
Attorney, Agent or Firm:
BEIJING CAI HE LAW FIRM (CN)
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