Title:
TARGETING PLURIPOTENT STEM CELLS TO TISSUES
Document Type and Number:
WIPO Patent Application WO2002036078
Kind Code:
A3
Abstract:
A non-naturally occurring method of modulating the targeting a pluripotent stem cell to a target tissue of a mammalian subject from another site in teh mammalian subject includes the step of: increasing or decreasing the concentration of SDF-1 alpha protein in the target tissue.
Inventors:
PETERSEN BRYON E
Application Number:
PCT/US2001/047225
Publication Date:
January 03, 2003
Filing Date:
November 05, 2001
Export Citation:
Assignee:
UNIV FLORIDA (US)
International Classes:
A61K38/19; A61K49/00; (IPC1-7): A01N37/18; A01N61/00; A61K48/00
Domestic Patent References:
| WO1999020759A1 | 1999-04-29 |
Foreign References:
| US5756084A | 1998-05-26 |
Other References:
AUITI, A. ET AL.: "The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood", J. EXP. MED., vol. 185, no. 1, 6 January 1997 (1997-01-06), pages 111 - 120, XP000866066
LUO, Z. ET AL.: "The role of positively charged residues in CXCR4 recognition probed with synthetic peptides", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATION, vol. 263, 1999, pages 691 - 695, XP000624788
LUO, Z. ET AL.: "The role of positively charged residues in CXCR4 recognition probed with synthetic peptides", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATION, vol. 263, 1999, pages 691 - 695, XP000624788
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