Title:
TAXADIENE SYNTHASE TCTS2, CODING NUCLEOTIDE SEQUENCE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/007542
Kind Code:
A1
Abstract:
Provided are a taxadiene synthase TcTS2, a encoding nucleotide sequence and use thereof. The amino acid sequence of TcTS2 comprises or consists of (a) an amino acid sequence set forth in SEQ ID NO: 1; or (b) a functional homologous sequence having at least 80% sequence similarity with the amino acid sequence set forth in SEQ ID NO: 1; or (c) an amino acid sequence having TcTS2 activity with addition, deletion, or substitution of one or more amino acids to the amino acid sequence set forth in SEQ ID NO: 1. The TcTS2 and the nucleotide sequence encoding the TcTS2 provide new gene resources for improving the yield of paclitaxel, can be used for modifying chassis hosts by means of plant genetic engineering and metabolic engineering strategies and producing paclitaxel and intermediates and the like thereof, and have significant economic and social value.
Inventors:
YAN JIANBIN (CN)
GOU JUNBO (CN)
LIAO QINGGANG (CN)
LIANG HAIFEI (CN)
LI CHONG (CN)
DU RAN (CN)
XIONG XINGYAO (CN)
HUANG SANWEN (CN)
GOU JUNBO (CN)
LIAO QINGGANG (CN)
LIANG HAIFEI (CN)
LI CHONG (CN)
DU RAN (CN)
XIONG XINGYAO (CN)
HUANG SANWEN (CN)
Application Number:
PCT/CN2021/097561
Publication Date:
January 13, 2022
Filing Date:
June 01, 2021
Export Citation:
Assignee:
AGRICULTURAL GENOMICS INST AT SHENZHEN CHINESE ACADEMY OF AGRICULTURAL SCIENCES (CN)
International Classes:
C12N9/88; C12N15/60; C12N15/82; C12P17/02
Domestic Patent References:
| WO2007081772A2 | 2007-07-19 | |||
| WO2005080579A2 | 2005-09-01 |
Foreign References:
| CN111748547A | 2020-10-09 | |||
| US20100297722A1 | 2010-11-25 | |||
| CN102812129A | 2012-12-05 | |||
| CN101001947A | 2007-07-18 | |||
| CN107674881A | 2018-02-09 |
Other References:
XIONG XINGYAO; GOU JUNBO; LIAO QINGGANG; LI YANLIN; ZHOU QIAN; BI GUIQI; LI CHONG; DU RAN; WANG XIAOTONG; SUN TIANSHU; GUO LVJUN; : "The Taxus genome provides insights into paclitaxel biosynthesis", NATURE PLANTS, NATURE PUBLISHING GROUP UK, LONDON, vol. 7, no. 8, 15 July 2021 (2021-07-15), London , pages 1026 - 1036, XP037540052, DOI: 10.1038/s41477-021-00963-5
DATABASE Nucleotide GenBank; ANONYMOUS : "Synthetic construct taxa-4(5),11(12)-diene synthase mRNA, complete cds ", XP055886692, retrieved from NCBI
DATABASE Nucleotide GenBank; ANONYMOUS : "Synthetic construct taxa-4(5),11(12)-diene synthase mRNA, complete cds ", XP055886692, retrieved from NCBI
Attorney, Agent or Firm:
BEIJING BRIGHT IP AGENCY CO., LTD. (CN)
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