Title:
TAXANE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1999/032473
Kind Code:
A1
Abstract:
Taxane derivatives represented by general formula (1) or salts thereof and drugs containing the same as the active ingredient wherein A?1¿ represents (a) (wherein R?1¿ represents H or optionally substituted alkyl) or (b) (wherein R?2¿ represents amino, mono- or dialkylamino, piperidino, pyrrolidino or morpholino); X represents H, alkoxycarbonyl or benzoyl; Y represents H or trialkylsilyl; A?2¿ represents furyl, alkylfuryl, alkyl or fluorophenyl; Ac represents acetyl; and Bz represents benzoyl. These compounds are excellent in solubility in water and antitumor activity.
Inventors:
SHIMIZU HIDEAKI (JP)
ABE ATSUHIRO (JP)
OGAWA TAKANORI (JP)
NAGATA HIROSHI (JP)
SAWADA SEIGO (JP)
ABE ATSUHIRO (JP)
OGAWA TAKANORI (JP)
NAGATA HIROSHI (JP)
SAWADA SEIGO (JP)
Application Number:
PCT/JP1998/005681
Publication Date:
July 01, 1999
Filing Date:
December 16, 1998
Export Citation:
Assignee:
YAKULT HONSHA KK (JP)
SHIMIZU HIDEAKI (JP)
ABE ATSUHIRO (JP)
OGAWA TAKANORI (JP)
NAGATA HIROSHI (JP)
SAWADA SEIGO (JP)
SHIMIZU HIDEAKI (JP)
ABE ATSUHIRO (JP)
OGAWA TAKANORI (JP)
NAGATA HIROSHI (JP)
SAWADA SEIGO (JP)
International Classes:
C07D305/14; C07D405/12; C07D405/14; C07D407/12; (IPC1-7): C07D305/14; A61K31/445; A61K31/495; C07D405/10; C07D409/10; C07D413/14
Domestic Patent References:
| WO1998002426A1 | 1998-01-22 |
Foreign References:
| JPH08253465A | 1996-10-01 |
Other References:
DIDIER E., ET AL.: "2-MONOSUBSTITUTED-1,3-OXAZOLIDINES AS IMPROVED PROTECTIVE GROUPS OFN-BOC-PHENYLISOSERINE IN DOCETAXEL PREPARATION.", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 35., no. 15., 1 January 1994 (1994-01-01), GB, pages 2349 - 2352., XP002922310, ISSN: 0040-4039, DOI: 10.1016/0040-4039(94)85217-0
See also references of EP 1044971A4
See also references of EP 1044971A4
Attorney, Agent or Firm:
Aruga, Mitsuyuki (Nihonbashiningyocho 1-chome Chuo-ku Tokyo, JP)
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