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Title:
TECHNIQUE FOR PREPARING AMORPHOUS POSACONAZOLE
Document Type and Number:
WIPO Patent Application WO/2016/061862
Kind Code:
A1
Abstract:
A technique for preparing an amorphous posaconazole. Posaconazole is dissolved in a mixed solvent of an alcohol and an ester, is added to an alkane, a cycloalkane, or an arene, and undergoes precipitation so as to separate out jelly-like solids, that is, amorphous posaconazole; the mass/volume ratio between the posaconazole and the mixed solvent (g/mL) is 1:4 to 1:10; the volume ratio between the alcohol and the ester in the mixed solvent is 1:3 to 1:20; the volume ratio between the mixed solvent and alkane or between the mixed solvent and the arene is 1:1 to 1:4.

Inventors:
DING, Zunliang (NO.528, East of Changjiang Road Jiangsu Yangtze River International Chemical Industrial Par, Zhangjiagang Jiangsu 5, 215635, CN)
WANG, Xilin (NO.528, East of Changjiang Road Jiangsu Yangtze River International Chemical Industrial Par, Zhangjiagang Jiangsu 5, 215635, CN)
Application Number:
CN2014/091350
Publication Date:
April 28, 2016
Filing Date:
November 18, 2014
Export Citation:
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Assignee:
JIANGSU HANSYN PHARMACEUTICAL CO., LTD (NO.528, East of Changjiang Road Jiangsu Yangtze River International Chemical Industrial Par, Zhangjiagang Jiangsu 5, 215635, CN)
International Classes:
C07D405/14; C07D295/135; C07D307/16; C07D405/06; C07D407/14
Domestic Patent References:
2013-03-28
1999-04-15
Foreign References:
US5625064A1997-04-29
US5661151A1997-08-26
Attorney, Agent or Firm:
NANJING JINGWEI PATENT & TRADEMARK AGENCY CO.,LTD (12th FL, -BNo.179 Zhongshan Road, Gulo, Nanjing Jiangsu 5, 210005, CN)
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