Title:
TELOMERASE INTERFERENCE
Document Type and Number:
WIPO Patent Application WO2003035667
Kind Code:
A3
Abstract:
The invention relates to nucleic acids encoding or comprising interfering RNAs which target telomerase RNA or mRNA encoding the telomerase reverse transcriptase (TERT). The invention includes methods for inhibiting telomerase activity expression vectors, and pharmaceutical compositions.
Inventors:
ROWLEY PETER T (US)
Application Number:
PCT/US2002/033065
Publication Date:
June 05, 2003
Filing Date:
October 16, 2002
Export Citation:
Assignee:
UNIV ROCHESTER (US)
ROWLEY PETER T (US)
ROWLEY PETER T (US)
International Classes:
C12N15/113; A61K38/00; (IPC1-7): C07H21/02; A61K48/00; C07H21/04; C12N15/85; C12N15/86; C12P19/34; C12Q1/68
Domestic Patent References:
| WO1998014592A2 | 1998-04-09 |
Foreign References:
| US6331399B1 | 2001-12-18 | |||
| US6166178A | 2000-12-26 | |||
| US20020098582A1 | 2002-07-25 | |||
| US20030040111A1 | 2003-02-27 |
Other References:
KYO ET AL.: "Telomerase activity in cancer as a diagnostic and therapeutic target", HISTOL. HISTOPATHOL., vol. 15, March 2000 (2000-03-01), pages 813 - 824, XP000965412
PARRISH ET AL.: "Functional anatomy of a dsRNA trigger: differentiation requirement for the two trigger strands in RNA interference", MOLECULAR CELL, vol. 6, November 2000 (2000-11-01), pages 1077 - 1087, XP002226361
FIRE ET AL.: "Protent and specific genetic interference by double-stranded RNA in caenorhabditis elegans", NATURE, vol. 391, 19 February 1998 (1998-02-19), pages 806 - 811, XP002938528
CAPLEN ET AL.: "Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems", PROC. NATL. ACAD. SCI. USA, vol. 98, no. 17, 14 August 2001 (2001-08-14), pages 9742 - 9747, XP002232936
See also references of EP 1448582A4
PARRISH ET AL.: "Functional anatomy of a dsRNA trigger: differentiation requirement for the two trigger strands in RNA interference", MOLECULAR CELL, vol. 6, November 2000 (2000-11-01), pages 1077 - 1087, XP002226361
FIRE ET AL.: "Protent and specific genetic interference by double-stranded RNA in caenorhabditis elegans", NATURE, vol. 391, 19 February 1998 (1998-02-19), pages 806 - 811, XP002938528
CAPLEN ET AL.: "Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems", PROC. NATL. ACAD. SCI. USA, vol. 98, no. 17, 14 August 2001 (2001-08-14), pages 9742 - 9747, XP002232936
See also references of EP 1448582A4
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