Title:
TEMPERATURE-SENSITIVE CHITOSAN HYDROGEL COMPOSITION AND BIOINK COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2020/262817
Kind Code:
A1
Abstract:
The present invention relates to a chitosan hydrogel composition comprising chitosan, glycerol, and a phosphate group, wherein the chitosan is crosslinked by glycerol, a phosphate group, or a combination thereof. The chitosan hydrogel composition enables temperature control for inducing a liquid-state composition into a gel state according to the content ratio of a phosphate group and glycerol, and since the concentration of gelatin affects the printing characteristics, strength, and the like, can be used as ink for 3D printers.
Inventors:
CHA MI SUN (KR)
KIM JUNG JU (KR)
KIM JUNG JU (KR)
Application Number:
PCT/KR2020/005440
Publication Date:
December 30, 2020
Filing Date:
April 24, 2020
Export Citation:
Assignee:
MEDIFAB CO LTD (KR)
International Classes:
A61L27/52; A61L27/20; A61L27/22; A61L27/38; A61L27/56; C09D11/04; C12N5/00
Foreign References:
| KR20180117417A | 2018-10-29 |
Other References:
CROISIER. F ET AL.: "Chitosan-based biomaterialsfor tissue engineering", EUROPEANPOLYMER JOURNAL, vol. 49, no. 4, 2013, pages 780 - 792, XP029001321
CHENG, Y. H. ET AL.: "Thermosensitive Chitosan-Gelatin-Glycerol Phosphate Hydrogels as a Cell Carrier for Nucleus Pulposus Regeneration: An In Vitro Study", TISSUE ENGINEERING: PART A., vol. 16, no. 2, 2010, pages 695 - 703, XP055778372
CHENITE, A. ET AL.: "Novel injectable neutral solutions of chitosan form biodegradable gels in situ", BIOMATERIALS, vol. 21, no. 21, 2000, pages 2155 - 2161, XP004216030, DOI: 10.1016/S0142-9612(00)00116-2
OWCZARZ, P. ET AL.: "Injectable Chitosan Scaffolds with Calcium b-Glycerophosphate as the Only Neutralizing Agent", PROCESSES, vol. 7, no. 297, 19 May 2019 (2019-05-19), pages 1 - 18, XP055778376
CHENG, Y. H. ET AL.: "Thermosensitive Chitosan-Gelatin-Glycerol Phosphate Hydrogels as a Cell Carrier for Nucleus Pulposus Regeneration: An In Vitro Study", TISSUE ENGINEERING: PART A., vol. 16, no. 2, 2010, pages 695 - 703, XP055778372
CHENITE, A. ET AL.: "Novel injectable neutral solutions of chitosan form biodegradable gels in situ", BIOMATERIALS, vol. 21, no. 21, 2000, pages 2155 - 2161, XP004216030, DOI: 10.1016/S0142-9612(00)00116-2
OWCZARZ, P. ET AL.: "Injectable Chitosan Scaffolds with Calcium b-Glycerophosphate as the Only Neutralizing Agent", PROCESSES, vol. 7, no. 297, 19 May 2019 (2019-05-19), pages 1 - 18, XP055778376
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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