Title:
TEREPHTHALIC ACID DERIVATIVE HAVING RING-FUSED STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2020/138011
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a compound which has a retinoic acid receptor agonist activity and is useful as a medicine that is capable of treating and/or preventing a retinal degenerative disease. The compound of the present invention is a compound represented by general formula (1)(where R1 and W are the same as described in the specification), or a pharmaceutically acceptable salt thereof.
Inventors:
YOSHIDA MASAYUKI (JP)
KOZAWA YUJI (JP)
TSUJI NAOKI (JP)
KOZAWA YUJI (JP)
TSUJI NAOKI (JP)
Application Number:
PCT/JP2019/050447
Publication Date:
July 02, 2020
Filing Date:
December 24, 2019
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
A61K31/235; A61K31/265; A61K31/357; A61P27/02; C07C233/65; C07D317/40
Domestic Patent References:
| WO2007037188A1 | 2007-04-05 | |||
| WO2013005753A1 | 2013-01-10 | |||
| WO2019009265A1 | 2019-01-10 |
Foreign References:
| JP2007513161A | 2007-05-24 |
Other References:
TANG, S. ET AL.: "Experimental studies of effects of retinoic acid on the proliferation of retinal cells", ZHONGHUA YAN KE ZA ZHI] CHINESE JOURNAL OF OPHTHALMOLOGY, vol. 38, no. 2, 2002, pages 112 - 114, XP009518445, ISSN: 0412-4081
KELLEY, M. W. ET AL.: "Retinoic acid promotes differentiation of photoreceptors in vitro", DEVELOPMENT, vol. 120, no. 8, 1994, pages 2091 - 2102, XP055562766
JIANG, Y. ET AL.: "Design, synthesis, and biological characterization of tamibarotene analogs as anticancer agents", CHEMICAL BIOLOGY & DRUG DESIG N, vol. 88, no. 4, 2016, pages 542 - 555, XP055721617
KELLEY, M. W. ET AL.: "Retinoic acid promotes differentiation of photoreceptors in vitro", DEVELOPMENT, vol. 120, no. 8, 1994, pages 2091 - 2102, XP055562766
JIANG, Y. ET AL.: "Design, synthesis, and biological characterization of tamibarotene analogs as anticancer agents", CHEMICAL BIOLOGY & DRUG DESIG N, vol. 88, no. 4, 2016, pages 542 - 555, XP055721617
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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