Title:
TERMINALLY-BRANCHED POLYMERIC LINKERS AND POLYMERIC CONJUGATES CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO2002065988
Kind Code:
A3
Abstract:
Terminally-branched polymeric prodrug platforms capable of high degrees of loading are disclosed. In preferred aspects of the invention, the prodrug platform releases multiple parent compounds after each branch holding the active agent undergoes a benzyl elimination reaction. Methods of preparing the prodrugs and using the same in the treatment of mammals are also disclosed. In one preferred aspect, polymeric conjugates such as (I) are provided.
Inventors:
CHOE YUN HWANG
GREENWALD RICHARD B
GREENWALD RICHARD B
Application Number:
PCT/US2002/004781
Publication Date:
April 10, 2003
Filing Date:
February 19, 2002
Export Citation:
Assignee:
ENZON INC (US)
International Classes:
A61K31/136; A61K31/198; A61K31/704; A61K31/7068; A61K47/48; A61P35/00; A61P43/00; C08G65/329; C08G65/333; C08G85/00; (IPC1-7): C07D491/22; C07D317/70; C07D305/14; A61K31/335
Domestic Patent References:
WO1996023794A1 | 1996-08-08 | |||
WO1993024476A1 | 1993-12-09 |
Foreign References:
US6135655A | 2000-10-24 | |||
US5606047A | 1997-02-25 |
Other References:
See also references of EP 1362053A4
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