Title:
TERPENE SYNTHASES
Document Type and Number:
WIPO Patent Application WO2000017327
Kind Code:
A9
Abstract:
Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.
Inventors:
CHAPPELL JOSEPH
MANNA KATHLEEN R
NOEL JOSEPH P
STARKS COURTNEY M
MANNA KATHLEEN R
NOEL JOSEPH P
STARKS COURTNEY M
Application Number:
PCT/US1999/021419
Publication Date:
October 04, 2001
Filing Date:
September 17, 1999
Export Citation:
Assignee:
UNIV KENTUCKY RES DEPT (US)
SALK INST FOR BIOLOGICAL STUDI (US)
SALK INST FOR BIOLOGICAL STUDI (US)
International Classes:
C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/00; A01H5/00; C12N9/10; C12N9/12; C12N9/88; C12N15/09; C12N15/82; C12Q1/25; G01N33/68; C12R1/91; (IPC1-7): C12N9/10; C07K14/415; C12N15/54; C12N15/29; C12N9/88
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