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Title:
TERPINEOL AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/133429
Kind Code:
A1
Abstract:
The present invention discloses a terpineol and a preparation method and an application thereof. The terpineol has a structure represented by formulas (I) or (II). In formula (I), R is independently selected from C12 to C16 alkyl, -NR1R2, -SR3 or -OR4, wherein R1, R2, R3 and R4 are independently selected from C1 to C6 alkyl or -NO2, and the C1 to C6 alkyl may be substituted with OH; or the R1 or R2, together with an attaching N, form a five-membered or six-membered ring, wherein the five-membered or six-membered ring may contain one O or C=O. An activity test showed that the terpineol has an excellent effect against asthma, inflammation and pulmonary artery hypertension, showing great promise in the field of pharmaceuticals.

Inventors:
ZHU, Wanping (No.132, Tianmu Mount Road Xihu Distric, Hangzhou Zhejiang 7, 310007, CN)
HU, Yongzhou (No.132, Tianmu Mount Road Xihu Distric, Hangzhou Zhejiang 7, 310007, CN)
LIU, Xia (No.132, Tianmu Mount Road Xihu Distric, Hangzhou Zhejiang 7, 310007, CN)
KONG, Fanzhi (No.132, Tianmu Mount Road Xihu Distric, Hangzhou Zhejiang 7, 310007, CN)
WANG, Yuji (No.132, Tianmu Mount Road Xihu Distric, Hangzhou Zhejiang 7, 310007, CN)
Application Number:
CN2017/071217
Publication Date:
August 10, 2017
Filing Date:
January 16, 2017
Export Citation:
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Assignee:
ZHEJIANG ACADEMY OF TRADITIONAL CHINESE MEDICINE (No.132, Tianmu Mount Road Xihu Distric, Hangzhou Zhejiang 7, 310007, CN)
International Classes:
C07C67/14; A61K31/045; A61K31/22; A61K31/5375; C07C29/17; C07C31/135; C07C69/24; C07C229/12; C07C291/02; C07D211/74; C07D295/15
Domestic Patent References:
WO2013034416A12013-03-14
Foreign References:
CN103922927A2014-07-16
CN102416154A2012-04-18
Other References:
BIAN, RULIAN ET AL.: "THE PHARMACOLOGICAL PROPERTIES OF A NEW ANTIASTHMATIC DRUG, a-TERPINEOL", CHINESE PHARMACOLOGICAL BULLETIN, vol. 3, no. 6, 31 December 1987 (1987-12-31), pages 323 and 326, XP009507861, ISSN: 1001-1978
See also references of EP 3412649A4
Attorney, Agent or Firm:
HANGZHOU TIANQIN INTELLECTUAL PROPERTY AGENCY CO., LTD. (Room 501, ZhupinjinzuoNo.1 Jingzhou Road, Xihu Distric, Hangzhou Zhejiang 3, 310013, CN)
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