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Title:
TEST APPARATUS
Document Type and Number:
WIPO Patent Application WO2003048389
Kind Code:
A3
Abstract:
Test apparatus includes sample receiving means operable to receive a sample to be tested, sample manipulating means operable to manipulate a received sample, reagent receiving means operable to add to the received sample a reagent and result indicating means operable to indicate whether the received sample contains a substance reactable with the reagent; wherein two or more of the elements of the apparatus are provided on a common substrate. The apparatus is designed to test small size samples, for example a drop of blood or less, typically a sample of the order of 5 mu l. It includes manipulating means able to manipulate a small size sample and including electrical field generating means operable to move a sample under test through the apparatus. The elements of the apparatus are provided on a common substrate and the apparatus includes electrical manipulating means for manipulating a sample, at least one micropump pumping and mixing sample with a reagent and indicator means for indicating whether the reagent has indicated the existence of a specified component within the sample under test. The apparatus can be in the form a kit which provides a sterile, disposable, consumable laboratory-on-a-chip device.

Inventors:
BALACHANDRAN WAMADIVA (GB)
MALYAN BERESFORD (GB)
Application Number:
PCT/GB2002/005553
Publication Date:
October 02, 2003
Filing Date:
December 09, 2002
Export Citation:
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Assignee:
UNIV BRUNEL (GB)
BALACHANDRAN WAMADIVA (GB)
MALYAN BERESFORD (GB)
International Classes:
B01L3/00; B03C5/02; F04B19/00; G01N35/08; G01N37/00; G01N1/00; (IPC1-7): B01L3/00; G01N27/447; F04B1/00; F04B19/00; B03C5/02
Domestic Patent References:
WO1998010267A11998-03-12
WO2000000293A12000-01-06
Foreign References:
DE19860117A12000-07-13
US6294063B12001-09-25
Other References:
HELENE ANDERSSON: "Microdfluidic devices for biotechnology and organic chemical applications", 16 November 2001, TRITA-DISS 3248, TRITA-ILA 0101, ISSN: 0281-2878, DISSERTATION OF THE KUNGL TEKNISKA HÖGSKOLAN, DEPARTMENT OF SIGNALS, SENSORS AND SYSTEMS, STOCKHOLM, SWEDEN, XP002243890
RAMSEY J M ET AL: "APPLYING THE MICROELECTRONICS PARADIGM TO CHEMISTRY: THE LAB-ON-A- CHIP", ISA TECH/EXPO TECHNOLOGY UPDATE, INSTRUMENT SOCIETY OF AMERICA, SALEM, MA, US, vol. 1, no. PART 5, 1997, pages 253 - 266, XP000832971, ISSN: 1054-0032
ANDERSSON H ET AL: "A valve-less diffuser micropump for microfluidic analytical systems", SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. B72, 10 February 2001 (2001-02-10), pages 259 - 265, XP002243889, ISSN: 0925-4005
MADOU M ET AL: "LabCD:ACentrifuge-Mased Microfluidic Platform for Diagnostics", PROCEEDINGS OF THE SPIE, SPIE, BELLINGHAM, VA, US, vol. 3259, no. 26, 26 January 1998 (1998-01-26), pages 80 - 93, XP002116851
MANZ A ET AL: "MINIATURIZED TOTAL CHEMICAL ANALYSIS SYSTEMS: A NOVEL CONCEPT FOR CHEMICAL SENSING", SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. B01, no. 1 - 6, 1990, pages 244 - 248, XP002062625, ISSN: 0925-4005
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