Title:
TEST METHOD FOR DEPRESSION SYMPTOMS AND SCREENING METHOD OF THERAPEUTIC AGENT THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/049960
Kind Code:
A1
Abstract:
By analyzing intestinal bacterial flora, the present inventors found intestinal bacteria specific to depression symptoms. Detection of these bacteria enables differential diagnosis of depression symptoms associated with neuropsychiatric disorders, cancer or circulatory disorders. Moreover, these bacteria are usable as an index in screening a drug which is efficacious against depression symptoms. The present inventors also found intestinal bacteria showing a recovery to a level comparable to a control upon dosing of (R)-ketamine. Thus, a patient highly sensitive to (R)-ketamine can be selected by analyzing the intestinal bacterial flora.
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Inventors:
HASHIMOTO KENJI (JP)
Application Number:
PCT/JP2018/033121
Publication Date:
March 14, 2019
Filing Date:
September 07, 2018
Export Citation:
Assignee:
UNIV CHIBA NAT UNIV CORP (JP)
International Classes:
C12Q1/04; A61K31/137; A61P9/00; A61P25/24; A61P35/00; C12Q1/689; G01N33/15; G01N33/50
Domestic Patent References:
| WO2016167365A1 | 2016-10-20 |
Foreign References:
| JP2015078181A | 2015-04-23 |
Other References:
RODIN, G. ET AL.: "Treatment of depression in cancer patients", CURRENT ONCOLOGY, vol. 14, no. 5, 2007, pages 180 - 188, XP055590174
PUMAR, M.I. ET AL.: "Anxiety and depression- Important psychological comorbidities of COPD", J THORAC. DIS., vol. 6, no. 11, 2014, pages 1615 - 1631, XP055590176
MACEDO, DANIELLE ET AL.: "Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness", JOURNAL OF AFFECTIVE DISORDERS, vol. 208, 28 September 2016 (2016-09-28), pages 22 - 32, XP029834984
QU, YOUGE ET AL.: "Comparison of (R)-ketamine and lanicemine on depression-like phenotype and abnormal composition of gut microbiota in a social defeat stress model", SCIENTIFIC REPORTS, vol. 7, no. 15725, 16 November 2017 (2017-11-16), pages 1 - 10, XP055590180
YANG, CHUN ET AL.: "Possible role of the gut microbiota-brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model", TRANSLATIONAL PSYCHIATRY, vol. 7, no. 1294, 18 December 2017 (2017-12-18), pages 1 - 11, XP055590189
PUMAR, M.I. ET AL.: "Anxiety and depression- Important psychological comorbidities of COPD", J THORAC. DIS., vol. 6, no. 11, 2014, pages 1615 - 1631, XP055590176
MACEDO, DANIELLE ET AL.: "Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness", JOURNAL OF AFFECTIVE DISORDERS, vol. 208, 28 September 2016 (2016-09-28), pages 22 - 32, XP029834984
QU, YOUGE ET AL.: "Comparison of (R)-ketamine and lanicemine on depression-like phenotype and abnormal composition of gut microbiota in a social defeat stress model", SCIENTIFIC REPORTS, vol. 7, no. 15725, 16 November 2017 (2017-11-16), pages 1 - 10, XP055590180
YANG, CHUN ET AL.: "Possible role of the gut microbiota-brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model", TRANSLATIONAL PSYCHIATRY, vol. 7, no. 1294, 18 December 2017 (2017-12-18), pages 1 - 11, XP055590189
Attorney, Agent or Firm:
SHIRAKATA Yumiko (JP)
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