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Title:
TEST METHOD FOR PREDICTING EFFECTIVENESS AND SAFETY OF MULTI-KINASE INHIBITOR, TEST KIT, AND BIOMARKER
Document Type and Number:
WIPO Patent Application WO/2017/110764
Kind Code:
A1
Abstract:
Provided are a test method for predicting the effect of administering Regorafenib, and a test kit. Measurements are taken of the CCL-5 concentration and the VEGF-A concentration in a specimen collected from a patient, whereby the effectiveness of treatment on the patient and the risk of adverse events are estimated.

Inventors:
SUENAGA MITSUKUNI (JP)
MIZUNUMA NOBUYUKI (JP)
MASHIMA TETSUO (JP)
SEIMIYA HIROYUKI (JP)
Application Number:
JP2016/087859
Publication Date:
June 29, 2017
Filing Date:
December 20, 2016
Export Citation:
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Assignee:
JAPANESE FOUND FOR CANCER RES (JP)
International Classes:
G01N33/53
Domestic Patent References:
WO2011146725A12011-11-24
WO2014148557A12014-09-25
WO2015031604A12015-03-05
Foreign References:
JP2014521070A2014-08-25
JP2015527874A2015-09-24
Other References:
SHOTA FUKUOKA: "Regorafenib no Biomarker", MOLECULAR TARGETED THERAPY FOR CANCE R, vol. 12, no. 2, 20 June 2014 (2014-06-20), pages 210 - 215
ANNA KUBO: "Regorafenib ni yoru Kan Shogai Akka Yosoku Kanosei no Kent o", ANNUAL MEETING OF JAPANESE SOCIETY OF MEDICAL ONCOLOGY, vol. 12 th, 19 July 2014 (2014-07-19), pages 3 - 10-3
AZUSA KOMORI: "Regorafenib no Soki Koka Yosoku wa Kano ka? Shizuoka Gan.Aichi Gan Kyodo Kansatsu Kenkyu [2]", THE ANNUAL MEETING OF JAPAN SOCIETY OF CLINICAL ONCOLOGY, vol. 53 rd, 29 October 2015 (2015-10-29), pages 124 - 1
SHOZO OSERA: "Daichogan no Saishin Chiryo I. Soron Perspective of personalized (precise) cancer therapy based on predictive biomarkers", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 72, no. 1, 1 January 2014 (2014-01-01), pages 29 - 34
SHIN'YAKU, NEWS [ NIPPON HYOJUN SHOHIN BUNRUI BANGO] 874291 REGORAFENIB-JO (STIVARGA-JO® 40MG, vol. 62, no. 4, 31 August 2013 (2013-08-31), pages 327 - 329
MASAHIDE FUKUDO: "Studies on biomarker related to toxicity of molecular-targeted anticancer drugs toward safe and individualized therapy", ADVANCES IN PHARMACEUTICAL SCIENCES, vol. 32, 1 March 2016 (2016-03-01), pages 109 - 114
NAO KAKIZAWA: "Shinko Saihatsu Daichogan ni Taisuru Regorafenib Tekio Handan no Shihyo", ANNUAL CONGRESS OF JAPAN SURGICAL SOCIETY, vol. 116 th, 14 April 2016 (2016-04-14), pages 064 - 5
SUENAGA MITSUKUNI: "Serum VEGF-A and CCL5 levels as candidate biomarkers for efficacy and toxicity of regorafenib in patients with metastatic colorectal cancer", ONCOTARGET, vol. 7, no. 23, 7 June 2016 (2016-06-07), pages 34811 - 34823, XP055396494
Attorney, Agent or Firm:
SHIRAKATA YUMIKO (JP)
White form Yumiko (JP)
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