Title:
TESTOSTERONE SECRETAGOGUE
Document Type and Number:
WIPO Patent Application WO/2021/261490
Kind Code:
A1
Abstract:
The present invention addresses the problem of acquiring a promoter that promotes the synthesis and secretion of testosterone without any side effects. The present inventors searched for materials having significantly high ability to promote testosterone secretion among various natural materials and, as a result, found 11 materials that promote testosterone secretion more strongly than Leydig cells. Then, the present inventors identified relevant ingredients in 3 of these materials.
More Like This:
| WO/2001/095940 | SUSTAINED RELEASE COMPOSITIONS |
| WO/2002/091993 | ESTROGEN RECEPTOR MODULATORS |
Inventors:
INAGAKI YOSUKE (JP)
KATO EISUKE (JP)
KATO EISUKE (JP)
Application Number:
PCT/JP2021/023614
Publication Date:
December 30, 2021
Filing Date:
June 22, 2021
Export Citation:
Assignee:
JAPAN PHARMA CO LTD (JP)
International Classes:
A61P5/24; A23L33/105; A61K31/047; A61K31/216; A61K31/7048; A61K36/185; A61K36/23; A61K36/254; A61K36/258; A61K36/28; A61K36/48; A61K36/53; A61K36/535; A61K36/63; A61K36/73; A61K36/80; A61K36/899; A61P5/26; A61P15/12; A61K127/00
Foreign References:
| JP2013181031A | 2013-09-12 | |||
| JP2019213518A | 2019-12-19 |
Other References:
BENVENGA, S. ET AL.: "Effects of Myo-INOSITOL Alone and in Combination with Seleno-Lmethionine on Cadmium-Induced Testicular Damage in Mice", CURRENT MOLECULAR PHARMACOLOGY, vol. 12, no. 4, 15 October 2019 (2019-10-15), pages 311 - 323
FARZADI, L. ET AL.: "Effect of rosmarinic acid on sexual behavior in diabetic male rats", AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 5, no. 16, 29 October 2011 (2011-10-29), pages 1906 - 1910, XP055895823
FARSI AREZOO, KHAKI ARASH, FATHIAZAD FATEMEH, AFSHARI FATEMEH, HAJHOSSINI LALEH, KAHKI AMIR AFSHIN: "Improvement Effect of Rosmarinic Acid on Serum Testosterone Level after Exposing with Electromagnetic Fields", INTERNATIONAL JOURNAL OF WOMEN'S HEALTH AND REPRODUCTION SCIENCES, LULU PRESS, vol. 1, no. 2, 1 July 2013 (2013-07-01), pages 45 - 50, XP055895825, ISSN: 2330-4456, DOI: 10.15296/ijwhr.2013.08
GEORGY GEHAN S., MAHER OMAR: "Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, WILEY, US, vol. 31, no. 9, 1 September 2017 (2017-09-01), US , pages e21937, XP055895826, ISSN: 1095-6670, DOI: 10.1002/jbt.21937
KATO MASAKI, KATO MASAKI, TANI TSUBASA, TERAHARA NORIHIKO, TSUDA TAKANORI, JIN TIANRU: "The Anthocyanin Delphinidin 3-Rutinoside Stimulates Glucagon-Like Peptide-1 Secretion in Murine GLUTag Cell Line via the Ca2+/Calmodulin-Dependent Kinase II Pathway", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, vol. 10, no. 5, 11 May 2015 (2015-05-11), pages e0126157, XP055895828, DOI: 10.1371/journal.pone.0126157
DONA, G. ET AL.: "INOSITOL administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome", EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 166, no. 4, 2012, pages 703 - 710
FARZADI, L. ET AL.: "Effect of rosmarinic acid on sexual behavior in diabetic male rats", AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 5, no. 16, 29 October 2011 (2011-10-29), pages 1906 - 1910, XP055895823
FARSI AREZOO, KHAKI ARASH, FATHIAZAD FATEMEH, AFSHARI FATEMEH, HAJHOSSINI LALEH, KAHKI AMIR AFSHIN: "Improvement Effect of Rosmarinic Acid on Serum Testosterone Level after Exposing with Electromagnetic Fields", INTERNATIONAL JOURNAL OF WOMEN'S HEALTH AND REPRODUCTION SCIENCES, LULU PRESS, vol. 1, no. 2, 1 July 2013 (2013-07-01), pages 45 - 50, XP055895825, ISSN: 2330-4456, DOI: 10.15296/ijwhr.2013.08
GEORGY GEHAN S., MAHER OMAR: "Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, WILEY, US, vol. 31, no. 9, 1 September 2017 (2017-09-01), US , pages e21937, XP055895826, ISSN: 1095-6670, DOI: 10.1002/jbt.21937
KATO MASAKI, KATO MASAKI, TANI TSUBASA, TERAHARA NORIHIKO, TSUDA TAKANORI, JIN TIANRU: "The Anthocyanin Delphinidin 3-Rutinoside Stimulates Glucagon-Like Peptide-1 Secretion in Murine GLUTag Cell Line via the Ca2+/Calmodulin-Dependent Kinase II Pathway", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, vol. 10, no. 5, 11 May 2015 (2015-05-11), pages e0126157, XP055895828, DOI: 10.1371/journal.pone.0126157
DONA, G. ET AL.: "INOSITOL administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome", EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 166, no. 4, 2012, pages 703 - 710
Attorney, Agent or Firm:
IWAHASHI Yuji (JP)
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