Title:
TETRAAZA- OR N2S2- COMPLEXANTS, AND THEIR USE IN RADIODIAGNOSTICS OR RADIOTHERAPY
Document Type and Number:
WIPO Patent Application WO1998043678
Kind Code:
B1
Abstract:
The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hydrogen, and methods for making and using these compounds. Another aspect of the invention provides for the use of the chelation compounds described above in methods for diagnostic and therapeutic purposes. A diagnostic method is described for detecting the presence or absence of a target site within a mammalian host. This method comprises providing to cells a diagnostically effective dose of a compound of the present invention which contains a metal radionuclide, such as <99m>Tc and/or <111>In, and detecting the biodistribution of the radionuclide. A therapeutic method is described for delivering a radionuclide, such as <186>Re/<188>Re, <90>Y, and <153>Sm, to a target site within a mammalian host. This method comprises providing to cells a therapeutically effective dose of a chelate compound of the present invention.
Inventors:
KASINA SUDHAKAR
Application Number:
PCT/US1998/005858
Publication Date:
April 01, 1999
Filing Date:
March 26, 1998
Export Citation:
Assignee:
NEORX CORP (US)
International Classes:
A61K51/00; A61K51/04; A61K51/08; A61P35/00; C07C229/16; C07C229/18; C07C323/34; C07D257/10; C07D265/32; C07D285/00; C07D333/36; C07D495/04; C07D495/14; C07F5/00; C07F9/22; C07F9/38; C07F9/6524; C07F9/6553; C07F9/6561; C07F13/00; (IPC1-7): A61K51/04; A61K51/08
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