Title:
TETRACYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/135610
Kind Code:
A1
Abstract:
The present invention belongs to the field of pharmaceutical chemistry, and relates to a tetracyclic compound, a pharmaceutical composition thereof and use thereof. The compound is a tetracyclic compound as shown in formula I, or a pharmaceutically acceptable salt, a hydrate, a solvate, a stereoisomer, a tautomer, a metabolite or a prodrug thereof, wherein R1-R6 and L1, L2, L3, Z1, Z2, and X and Y groups are as defined in the description. The compound and the pharmaceutical composition comprising same in the present invention have good SOS1 inhibitory activity, and therefore can be used as an SOS1 inhibitor, and can be used for preparing drugs for treating and/or preventing diseases caused by overexpression of SOS1, such as cancer, thereby being applied in the field of medicines. The tetracyclic compound in the present invention exhibits excellent biological activity and druggability, and has great prospects for drug development.
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Inventors:
FANG HUAXIANG (CN)
YANG XIUMEI (CN)
YANG XIUMEI (CN)
Application Number:
PCT/CN2022/070423
Publication Date:
June 30, 2022
Filing Date:
January 06, 2022
Export Citation:
Assignee:
WUHAN YUXIANG PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C07D498/14; A61K31/5383; A61P35/00
Domestic Patent References:
| WO2018172250A1 | 2018-09-27 |
Foreign References:
| CN110167928A | 2019-08-23 | |||
| CN110603258A | 2019-12-20 |
Attorney, Agent or Firm:
WUHAN ZHI JIA JOINT INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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