Title:
TETRACYCLIC XANTHENE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
Document Type and Number:
WIPO Patent Application WO/2012/125926
Kind Code:
A3
Abstract:
The present invention relates to novel Tetracyclic Xanthene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, Y1, Y2, Z, Ra, Rb, R1a, R1b and R2 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Xanthene Derivative, and methods of using the Tetracyclic Xanthene Derivatives for treating or preventing HCV infection in a patient.
Inventors:
COBURN CRAIG A (US)
ROSENBLUM STUART B (US)
KOZLOWSKI JOSEPH A (US)
SOLL RICHARD (CN)
WU HAO (CN)
HU BIN (CN)
ZHONG BIN (CN)
WANG DAHAI (CN)
SHEN CHANGMAO (CN)
SUN FEI (CN)
ROSENBLUM STUART B (US)
KOZLOWSKI JOSEPH A (US)
SOLL RICHARD (CN)
WU HAO (CN)
HU BIN (CN)
ZHONG BIN (CN)
WANG DAHAI (CN)
SHEN CHANGMAO (CN)
SUN FEI (CN)
Application Number:
PCT/US2012/029446
Publication Date:
May 08, 2014
Filing Date:
March 16, 2012
Export Citation:
Assignee:
MERCK SHARP & DOHME (US)
COBURN CRAIG A (US)
ROSENBLUM STUART B (US)
KOZLOWSKI JOSEPH A (US)
SOLL RICHARD (CN)
WU HAO (CN)
HU BIN (CN)
ZHONG BIN (CN)
WANG DAHAI (CN)
SHEN CHANGMAO (CN)
SUN FEI (CN)
COBURN CRAIG A (US)
ROSENBLUM STUART B (US)
KOZLOWSKI JOSEPH A (US)
SOLL RICHARD (CN)
WU HAO (CN)
HU BIN (CN)
ZHONG BIN (CN)
WANG DAHAI (CN)
SHEN CHANGMAO (CN)
SUN FEI (CN)
International Classes:
C07F9/28; A01N43/50; C07D291/00; C07D498/00
Domestic Patent References:
| WO2010111534A1 | 2010-09-30 |
Foreign References:
| US20090202483A1 | 2009-08-13 | |||
| US20080044379A1 | 2008-02-21 | |||
| US3957989A | 1976-05-18 |
Other References:
DATABASE PUBMED [online] 9 February 2007 (2007-02-09), XP003032811, Database accession no. 14460074
Attorney, Agent or Firm:
MERCK SHARP & DOHME CORP (Rahway, New Jersey, US)
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