Title:
TETRACYCLINES FOR TREATING OCULAR DISEASES AND DISORDERS
Document Type and Number:
WIPO Patent Application WO2007067807
Kind Code:
B1
Abstract:
Methods and compositions are disclosed for treating a patient suffering from a condition associated with a retinal and/or choroidal disease or disorder of the eye involving endothelial cell dysfunction, especially vascular endothelial cells of the eye, and especially before or in the absence of neovascularization. The therapeutic method involves administering a tetracycline, an analog of tetracycline, or a chemically modified tetracycline (CMT) to a patient suffering from such conditions. Also provided are compositions and methods for reducing breakdown of tight junctions in vascular endothelial cells; reducing IL-1 a concentrations; and inhibiting IL-1 a-mediated matrix metalloproteinase activity in endothelial cells of the eye and surrounding tissues.
Inventors:
POWER DAVID F (US)
Application Number:
PCT/US2006/047174
Publication Date:
October 11, 2007
Filing Date:
December 07, 2006
Export Citation:
Assignee:
ALACRITY BIOSCIENCES INC (US)
POWER DAVID F (US)
POWER DAVID F (US)
International Classes:
A61K31/65; A61P27/02
Download PDF: