Title:
TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE
Document Type and Number:
WIPO Patent Application WO/2017/202360
Kind Code:
A1
Abstract:
A tetradentate chelating monoquinoline derivative as represented by formula (I). The derivative can specifically chelate to a redox-active metal ion, such as a copper ion, related to a neurodegenerative disease (Alzheimer's disease, Parkinson's disease, or amyotrophic lateral sclerosis) or metabolic disorder, or to a copper accumulation disease (Wilson's disease). A zinc ion stability constant of the derivative is 6-12 orders of magnitude lower than a copper ion stability constant thereof. The derivative also has stronger oxidative stress resistance. The derivative is easy to manufacture, and has potential applications in preparing a pharmaceutical product for treating a neurodegenerative disease or a pharmaceutical product for a disease related to a copper homeostasis disorder.
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Inventors:
LIU YAN (CN)
ZHANG WEIXIN (CN)
HUANG DAYA (CN)
HUANG MEIJIE (CN)
WANG DEAN (CN)
HUANG JU (CN)
SHU SIWEI (CN)
NGUYEN MICHEL (CN)
ROBERT ANNE (CN)
MEUNIER BERNARD (CN)
ZHANG WEIXIN (CN)
HUANG DAYA (CN)
HUANG MEIJIE (CN)
WANG DEAN (CN)
HUANG JU (CN)
SHU SIWEI (CN)
NGUYEN MICHEL (CN)
ROBERT ANNE (CN)
MEUNIER BERNARD (CN)
Application Number:
PCT/CN2017/085886
Publication Date:
November 30, 2017
Filing Date:
May 25, 2017
Export Citation:
Assignee:
UNIV GUANGDONG TECHNOLOGY (CN)
International Classes:
C07D215/40; A61K31/47; A61P25/00
Foreign References:
| US20140364454A1 | 2014-12-11 | |||
| CN105949120A | 2016-09-21 | |||
| US6277841B1 | 2001-08-21 | |||
| US7589209B2 | 2009-09-15 |
Other References:
See also references of EP 3466931A4
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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