Title:
TETRAHYDRO-1H-BENZAZEPINE COMPOUND AS POTASSIUM CHANNEL MODULATOR, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/238917
Kind Code:
A1
Abstract:
The present invention relates to a tetrahydro-1H-benzazepine compound as potassium channel modulator, a preparation method and a use thereof. Specifically, the compound of the present invention has the structure shown by formula A, wherein the definition of each group and substituent is as described in the description; the present invention also discloses a preparation method of the compound and its use as potassium channel modulator.
Inventors:
LIANG BO (CN)
JIN QIU (CN)
CHEN HUANMING (CN)
ZHANG ZHIJUN (CN)
HUA BO (CN)
JIN QIU (CN)
CHEN HUANMING (CN)
ZHANG ZHIJUN (CN)
HUA BO (CN)
Application Number:
PCT/CN2020/092401
Publication Date:
December 03, 2020
Filing Date:
May 26, 2020
Export Citation:
Assignee:
SHANGHAI ZHIMENG BIOPHARMA INC (CN)
International Classes:
C07D223/16; A61K31/55; A61P21/00; A61P25/00; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P31/04; A61P31/14; A61P31/22
Domestic Patent References:
| WO2008038053A1 | 2008-04-03 |
Foreign References:
| CN103508960A | 2014-01-15 | |||
| CN101795727A | 2010-08-04 | |||
| CN1777582A | 2006-05-24 | |||
| CN101084209A | 2007-12-05 |
Other References:
SAMBROOK ET AL.: "Molecular Cloning: Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
ZHAOBING GAO ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 36, 2010, pages 28322 - 28332
See also references of EP 3978478A4
ZHAOBING GAO ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 36, 2010, pages 28322 - 28332
See also references of EP 3978478A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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