TETRAHYDROBENZINDOLE COMPOUNDS - MEIJI SEIKA KAISHA

Title:

TETRAHYDROBENZINDOLE COMPOUNDS

Document Type and Number:

WIPO Patent Application WO/1998/000400

Kind Code:

A1

Abstract:

Compounds represented by general formula (I) and pharmaceutically acceptable salts thereof which strongly inhibit [?3�H]-serotonin and [?3�H]-5-CT binding to the human serotonin 5-HT�7? receptor subtype expressed in a cultured cell line and can provide medicinal compositions for treating or preventing mental diseases. In said formula (I) A represents N, CH, C having a double bond or CR?5�; B and Z independently represent each N, CH or CR?1�, provided that A is N when B and/or Z is N; R?1� represents hydrogen, halogeno, lower alkyl, cyano, trihalomethyl, hydroxy, alkoxy, alkylthio, alkylsulfenyl, alkylsulfonyl, alkoxycarbonyl, sulfamoyl, optionally substituted amino, optionally alkylated carbamoyl, acyl or carboxy; R?2� represents hydrogen or lower alkyl; R?3� represents hydrogen, lower alkyl or aralkyl; R?4� represents hydrogen, halogeno, lower alkyl, hydroxyl, alkoxy, acyl, alkoxycarbonyl, nitro, optionally substituted amino, optionally alkylated carbamoyl or acyloxy; R?5� represents lower alkyl, cyano, carbamoyl, carboxy, acyl, acyloxy, alkoxy, alkoxycarbonyl, trihalomethyl or hydroxy; and n is an integer of from 2 to 6.

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Inventors:

KOYAMA MASAO (JP)
KIKUCHI CHIKA (JP)
USHIRODA OSAMU (JP)
ANDO TAKASHI (JP)
NAGASO HIROSHI (JP)
FUJI KAZUYUKI (JP)
OKUNO MASAYO (JP)
HIRANUMA TOYOKAZU (JP)

Application Number:

PCT/JP1997/002226

Publication Date:

January 08, 1998

Filing Date:

June 27, 1997

Export Citation:

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Assignee:

MEIJI SEIKA KAISHA (JP)
KOYAMA MASAO (JP)
KIKUCHI CHIKA (JP)
USHIRODA OSAMU (JP)
ANDO TAKASHI (JP)
NAGASO HIROSHI (JP)
FUJI KAZUYUKI (JP)
OKUNO MASAYO (JP)
HIRANUMA TOYOKAZU (JP)

International Classes:

A61P25/18; C07D209/92; C07D401/06; C07D401/12; C07D403/12; (IPC1-7): C07D209/92; C07D401/06; C07D401/12; C07D403/12; A61K31/445; A61K31/535

Foreign References:

JPH03190858A	1991-08-20
JPH04230377A	1992-08-19

Other References: