TETRAHYDROBENZOTHIOPHENE COMPOUND

WIPO Patent Application WO/2011/136269

A1

Disclosed is a compound which has an intestinal phosphate transporter (NPT-IIb) inhibition activity and is useful as an active ingredient for a therapeutic agent and/or a prophylactic agent for hyperphosphatemia. A tetrahydrobenzothiophene compound represented by formula (I) has an NPT-IIb inhibition activity and can be used as a prophylactic agent and/or a therapeutic agent for hyperphosphatemia. (In the formula, R1 represents -O-(lower alkyl), -(lower alkylene)-phenyl, or the like; R2 and R3 are same as or different from each other and independently represent H, a lower alkyl group, a cycloalkyl group, an aryl group, a heteroaryl group, or the like, or R2, R3 and a nitrogen atom to which R2 and R3 are bound together may form a 5- to 7-membered saturated cyclic amino group; R4's are same as or different from each other and independently represent a halogen atom, a lower alkyl group, or the like; and n represents 0 to 2.)

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HACHIYA SHUNICHIRO (JP)
MIURA MASANORI (JP)
IMAMURA YOSHIMASA (JP)
KAGA DAISUKE (JP)
SATO IPPEI (JP)
MORITOMO HIROYUKI (JP)
KATO KOJI (JP)
TERAI KAZUHIRO (JP)
TERADA YOH (JP)

PCT/JP2011/060261

November 03, 2011

April 27, 2011

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ASTELLAS PHARMA INC (JP)
HACHIYA SHUNICHIRO (JP)
MIURA MASANORI (JP)
IMAMURA YOSHIMASA (JP)
KAGA DAISUKE (JP)
SATO IPPEI (JP)
MORITOMO HIROYUKI (JP)
KATO KOJI (JP)
TERAI KAZUHIRO (JP)
TERADA YOH (JP)

C07D333/68; A61K31/381; A61K31/4025; A61K31/4436; A61K31/4535; A61K31/496; A61K31/5377; A61K31/55; A61P3/12; A61P9/00; A61P13/12; A61P43/00; C07D409/12

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MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)

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