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Patent Searching and Data


Title:
TETRAHYDROCARBOLINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2012/005227
Kind Code:
A1
Abstract:
As a pharmaceutical product useful for patients with urine evacuation disorders for whom conventional drugs are ineffective, a drug is disclosed having inhibitory activity on ENPP2, which is a target different from that of already existing drugs. Disclosed are a compound represented by formula (I) (wherein definitions of the groups are as in the description) having ENPP2 inhibitory activity, a salt or solvate thereof, a prodrug of either of these, or an agent for prevention, treatment and/or symptomatic improvement of urine evacuation disorders containing either of these as an active ingredient.

Inventors:
OHATA AKIRA (JP)
NAKATANI SHINGO (JP)
SUGIYAMA TETSUYA (JP)
MORIMOTO TAKASHI (JP)
Application Number:
PCT/JP2011/065312
Publication Date:
January 12, 2012
Filing Date:
July 05, 2011
Export Citation:
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Assignee:
ONO PHARMACEUTICAL CO (JP)
OHATA AKIRA (JP)
NAKATANI SHINGO (JP)
SUGIYAMA TETSUYA (JP)
MORIMOTO TAKASHI (JP)
International Classes:
C07D471/04; A61K31/437; A61K31/4375; A61K31/4545; A61K31/497; A61K45/00; A61P11/00; A61P13/00; A61P13/08; A61P17/00; A61P19/02; A61P21/00; A61P29/00; A61P35/00; A61P43/00; C07D471/14
Foreign References:
JP2003533453A2003-11-11
JP2007518822A2007-07-12
JP2004518730A2004-06-24
Other References:
XIAOMING ZHANG ET AL.: "Oxidative methods for promoting iminium cation cyclization reactions", TETRAHEDRON LETTERS, vol. 34, no. 33, 1993, pages 5239 - 5242, XP055101372
See also references of EP 2592081A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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Claims: