Title:
TETRAHYDROIMIDAZO[1,5-D][1,4]OXAZEPINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2014/133022
Kind Code:
A1
Abstract:
A compound represented by general formula (I) [wherein R represents a hydrogen atom, a C1-6 alkyl group or the like; R1 represents a C1-6 alkyl group, a C1-6 alkoxy group or the like; R2 represents a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or the like; R3 represents a hydrogen atom, a C1-6 alkyl group or the like; and R4 represents a C1-6 alkyl group or the like] or a pharmaceutically acceptable salt thereof, which is an antagonist of mGluR2 and can be used as a therapeutic agent for neurological disorders associated with mGluR2-associated glutamate dysfunction and diseases, such as Alzheimer's disease.
Inventors:
TAKAISHI MAMORU (JP)
SATO NOBUHIRO (JP)
SHIBUGUCHI TOMOYUKI (JP)
MOTOKI TAKAFUMI (JP)
TAKAHASHI YOSHINORI (JP)
SASAKI TAKEO (JP)
BRAUNTON ALAN (GB)
SATO NOBUHIRO (JP)
SHIBUGUCHI TOMOYUKI (JP)
MOTOKI TAKAFUMI (JP)
TAKAHASHI YOSHINORI (JP)
SASAKI TAKEO (JP)
BRAUNTON ALAN (GB)
Application Number:
PCT/JP2014/054724
Publication Date:
September 04, 2014
Filing Date:
February 26, 2014
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
C07D498/04; A61K31/553; A61P25/28
Domestic Patent References:
| WO2010068520A2 | 2010-06-17 | |||
| WO2007139149A1 | 2007-12-06 |
Foreign References:
| JP2009510011A | 2009-03-12 | |||
| JP2012510437A | 2012-05-10 | |||
| JP2008534455A | 2008-08-28 | |||
| JP2012513399A | 2012-06-14 |
Other References:
SCIENCE, vol. 258, 1992, pages 597 - 603
TRENDS PHARMACOL. SCI., vol. 14, 1993, pages 13
NEUROPHARMACOL., vol. 46, no. 7, 2004, pages 907 - 917
PHARMACOL. THERAPEUTICS, vol. 104, no. 3, 2004, pages 233 - 244
NEUROPHARMACOL., vol. 66, 2013, pages 40 - 52
J. MASS SPECTRUM. SOC. JPN., vol. 51, no. 5, 2003, pages 492 - 498
See also references of EP 2963043A4
TRENDS PHARMACOL. SCI., vol. 14, 1993, pages 13
NEUROPHARMACOL., vol. 46, no. 7, 2004, pages 907 - 917
PHARMACOL. THERAPEUTICS, vol. 104, no. 3, 2004, pages 233 - 244
NEUROPHARMACOL., vol. 66, 2013, pages 40 - 52
J. MASS SPECTRUM. SOC. JPN., vol. 51, no. 5, 2003, pages 492 - 498
See also references of EP 2963043A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Yoshiki Hasegawa (JP)
Yoshiki Hasegawa (JP)
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