Title:
TETRAHYDROISOQUINOLINE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2019/137985
Kind Code:
A1
Abstract:
The present invention relates to a novel class of tetrahydroisoquinoline compounds of formula I and to compositions comprising the same. The compounds and compositions of the present invention can be used as medicaments in the treatment of cancer.
Inventors:
VEGA GARCÍA MIGUEL (ES)
CAMPOS MUELAS PEDRO (ES)
CARRASCO ROMERO ESTHER (ES)
BURGUETE PÉREZ ASUNCIÓN (ES)
GÓMEZ GUTIÉRREZ PATRICIA (ES)
PÉREZ GONZÁLEZ JUAN JESÚS (ES)
MESSEGUER PEYPOCH ÁNGEL (ES)
ALARCÓN SÁNCHEZ BALBINO JOSÉ (ES)
ARELLANO ROJO IRENE AZHARA (ES)
CAMPOS MUELAS PEDRO (ES)
CARRASCO ROMERO ESTHER (ES)
BURGUETE PÉREZ ASUNCIÓN (ES)
GÓMEZ GUTIÉRREZ PATRICIA (ES)
PÉREZ GONZÁLEZ JUAN JESÚS (ES)
MESSEGUER PEYPOCH ÁNGEL (ES)
ALARCÓN SÁNCHEZ BALBINO JOSÉ (ES)
ARELLANO ROJO IRENE AZHARA (ES)
Application Number:
PCT/EP2019/050518
Publication Date:
July 18, 2019
Filing Date:
January 10, 2019
Export Citation:
Assignee:
ALLINKY BIOPHARMA (ES)
International Classes:
C07D405/14; A61K31/472; A61K31/4725; A61P35/00; C07D217/24; C07D401/12; C07D413/12; C07D413/14; C07D417/12; C07D487/04
Domestic Patent References:
| WO2016033105A1 | 2016-03-03 | |||
| WO2000078708A1 | 2000-12-28 | |||
| WO2009055077A1 | 2009-04-30 | |||
| WO2011017125A1 | 2011-02-10 | |||
| WO2015089337A1 | 2015-06-18 |
Foreign References:
| US20100249115A1 | 2010-09-30 |
Other References:
NAGORE I. MARÍN-RAMOS ET AL: "Blocking Ras inhibition as an antitumor strategy", SEMINARS IN CANCER BIOLOGY., 1 February 2018 (2018-02-01), US, XP055479942, ISSN: 1044-579X, DOI: 10.1016/j.semcancer.2018.01.017
CHUN XIE ET AL: "Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells", FRONTIERS IN PHARMACOLOGY, vol. 8, 14 November 2017 (2017-11-14), XP055479954, DOI: 10.3389/fphar.2017.00823
G. LIU. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, 2007, pages 3086 - 3100
A. YOKOHAMA ET AL., JOURNAL OF ORGANIC CHEMISTRY, vol. 64, 1999, pages 611 - 617
R. GITTO ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, 2003, pages 197 - 200
J. E. DE LOS ANGELES, JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, 1996, pages 3701 - 3711
G. FODOR ET AL., ANGEWANDTE CHEMIE INT. ED., vol. 11, 1972, pages 919 - 920
G. LIU ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, 2007, pages 3086 - 3100
CHUN XIE ET AL: "Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells", FRONTIERS IN PHARMACOLOGY, vol. 8, 14 November 2017 (2017-11-14), XP055479954, DOI: 10.3389/fphar.2017.00823
G. LIU. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, 2007, pages 3086 - 3100
A. YOKOHAMA ET AL., JOURNAL OF ORGANIC CHEMISTRY, vol. 64, 1999, pages 611 - 617
R. GITTO ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, 2003, pages 197 - 200
J. E. DE LOS ANGELES, JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, 1996, pages 3701 - 3711
G. FODOR ET AL., ANGEWANDTE CHEMIE INT. ED., vol. 11, 1972, pages 919 - 920
G. LIU ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, 2007, pages 3086 - 3100
Attorney, Agent or Firm:
HOFFMANN EITLE S.L.U. (ES)
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