Title:
TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/184744
Kind Code:
A1
Abstract:
The present invention relates to a tetrahydroisoquinoline derivative, a preparation method therefor and uses thereof, and more particularly relates to a tetrahydroisoquinoline derivative or a pharmaceutically acceptable salt, an ester, a stereoisomer, a tautomer, a polymorph, a solvate, an isotope-labeled compound, a metabolite or a prodrug. The present invention further relates to a preparation method therefor, an intermediate, a pharmaceutical composition comprising said compound, and uses thereof in the treatment or prevention of thromboembolic disorders.
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Inventors:
WU YONGYONG (CN)
CAI JIAQIANG (CN)
ZHANG GUANGCHAO (CN)
DUAN SHUANGSHUANG (CN)
WANG CHAOLEI (CN)
WANG LICHUN (CN)
WANG JINGYI (CN)
CAI JIAQIANG (CN)
ZHANG GUANGCHAO (CN)
DUAN SHUANGSHUANG (CN)
WANG CHAOLEI (CN)
WANG LICHUN (CN)
WANG JINGYI (CN)
Application Number:
PCT/CN2019/078493
Publication Date:
October 03, 2019
Filing Date:
March 18, 2019
Export Citation:
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07D413/14; A61K31/4725; A61K31/496; A61P7/02; A61P9/10; C07D401/06; C07D401/14; C07D413/06; C07D498/04
Domestic Patent References:
| WO2013055984A1 | 2013-04-18 | |||
| WO2013056060A1 | 2013-04-18 |
Foreign References:
| CN103974938A | 2014-08-06 | |||
| CN107540659A | 2018-01-05 | |||
| CN103987696A | 2014-08-13 | |||
| CN105228996A | 2016-01-06 | |||
| CN107540659A | 2018-01-05 |
Other References:
J. RAUTIO ET AL., NATURE REVIEWS DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270
"Prodrugs: Challenges and Rewards", 2007, SPRINGER
"Protective Groups in Organic Synthesis", 2006, WILEY-INTERSCIENCE
See also references of EP 3778597A4
"Prodrugs: Challenges and Rewards", 2007, SPRINGER
"Protective Groups in Organic Synthesis", 2006, WILEY-INTERSCIENCE
See also references of EP 3778597A4
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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