Title:
TETRAHYDROOXAZOLO-PYRIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2014/065270
Kind Code:
A1
Abstract:
Provided is a therapeutic agent for neurodegenerative disorders and psychiatric disorders related to mGluR5, the therapeutic agent comprising a compound represented by formula (I) or a pharmaceutically acceptable salt of the same (in the formula, R1 represents a halogen, methyl or cyano, and R2 and R3 each independently represents a hydrogen atom, a halogen, a C1-3 alkyl, a C1-3 alkoxy or a cyano), having the function of a metabotropic glutamic acid receptor sub-type 5 (mGluR5) negative modulator, having oral absorption properties with excellent pharmacokinetics, having high bioavailability and excellent stability.
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Inventors:
YOSHIDA KOZO (JP)
HIROSE WATARU (JP)
HIROSE WATARU (JP)
Application Number:
PCT/JP2013/078553
Publication Date:
May 01, 2014
Filing Date:
October 22, 2013
Export Citation:
Assignee:
DAINIPPON SUMITOMO PHARMA CO (JP)
International Classes:
C07D498/04; A61K31/444; A61P9/00; A61P9/10; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P43/00; C07K14/705; C12N15/09
Domestic Patent References:
| WO2010114971A1 | 2010-10-07 | |||
| WO2012004373A1 | 2012-01-12 |
Foreign References:
| JP2005514382A | 2005-05-19 | |||
| JPH0377887A | 1991-04-03 |
Other References:
BURDI,D.F. ET AL., J.MED.CHEM., vol. 53, 2010, pages 7107 - 7118
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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