Title:
TETRAHYDROPALMATINE DERIVATIVES AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/041515
Kind Code:
A1
Abstract:
Provided are compounds of formula (VI), a preparation method therefor and a pharmaceutical application of said compounds. The compounds can increase LDLR expression and reduce PCSK9 expression, and can be used for preventing and treating hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, type 2 diabetes, hyperglycemia, obesity, insulin resistance syndrome and metabolic syndrome.
Inventors:
LI DE QUN (CN)
Application Number:
PCT/CN2015/089881
Publication Date:
March 24, 2016
Filing Date:
September 17, 2015
Export Citation:
Assignee:
CHENGDU BESTCHIRALBIO LTD LIABILITY COMPANY (CN)
International Classes:
C07D455/03; A61K31/4375; A61P3/00; A61P3/06
Domestic Patent References:
| WO2010075469A1 | 2010-07-01 | |||
| WO2011006000A1 | 2011-01-13 |
Other References:
DATABASE REGISTRY 19 September 2014 (2014-09-19), AMERICAN CHEMICAL SOCIETY, Database accession no. 1623791-35-4
DATABASE REGISTRY AMERICAN CHEMICAL SOCIETY, Database accession no. N1556098-36-2
DATABASE REGISTRY AMERICAN CHEMICAL SOCIETY, Database accession no. N1556098-36-2
Attorney, Agent or Firm:
BOSS & YOUNG PATENT AND TRADEMARK LAW OFFICE et al. (CN)
北京邦信阳专利商标代理有限公司 (CN)
北京邦信阳专利商标代理有限公司 (CN)
Download PDF:
Previous Patent: TETRAHYDROBERBERINE DERIVATIVES AND APPLICATION THEREOF
Next Patent: KEY SWITCH, KEY UNIT AND COMPUTER KEYBOARD
Next Patent: KEY SWITCH, KEY UNIT AND COMPUTER KEYBOARD