Title:
TETRAHYDROPYRAN HETEROCYCLIC CYCLOPENTYL HETEROARYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
Document Type and Number:
WIPO Patent Application WO2005014537
Kind Code:
A3
Abstract:
The present invention is further directed to compounds of the formulas: (I) (II) (wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, R<10>, R<15>, R<16>, R<17>, R<18>, R<19>, R<24> and R<25> are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
Inventors:
BUTORA GABOR (US)
YANG LIHU (US)
GOBLE STEPHEN D (US)
YANG LIHU (US)
GOBLE STEPHEN D (US)
Application Number:
PCT/US2004/025467
Publication Date:
May 12, 2005
Filing Date:
August 06, 2004
Export Citation:
Assignee:
MERCK & CO INC (US)
BUTORA GABOR (US)
YANG LIHU (US)
GOBLE STEPHEN D (US)
BUTORA GABOR (US)
YANG LIHU (US)
GOBLE STEPHEN D (US)
International Classes:
C07D407/12; C07D; (IPC1-7): C07D407/12
Foreign References:
| US4048180A | 1977-09-13 |
Other References:
See also references of EP 1654256A4
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