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Patent Searching and Data


Title:
TETRAHYDROPYRANOOXAZINE DERIVATIVES HAVING SELECTIVE BACE1 INHIBITORY ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2019/208693
Kind Code:
A1
Abstract:
The present invention provides a compound which has an effect of inhibiting amyloid βproduction, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid βproteins. A compound of Formula (I)wherein R3 is each independently alkyl optionally substituted with halogen, cyano, alkyloxy, haloalkyloxy or non-aromatic carbocyclyl, or the like; t is integer from 0 to 3; R5 is a hydrogen atom or halogen; R6 is selected from the group consisting of a hydrogen atom, halogen, and substituted or unsubstituted alkyl;ring B is a substituted or unsubstituted pyrazine or the like;, or a pharmaceutically acceptable salt thereof.

Inventors:
TADANO GENTA (JP)
SUZUKI SHINJI (JP)
KUSAKABE KEN-ICHI (JP)
Application Number:
JP2019/017619
Publication Date:
October 31, 2019
Filing Date:
April 25, 2019
Export Citation:
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Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D498/04; A61K31/5365; A61P25/00
Domestic Patent References:
WO2014001228A12014-01-03
WO2012107371A12012-08-16
WO2015156421A12015-10-15
WO2014065434A12014-05-01
WO2014001228A12014-01-03
WO2013041499A12013-03-28
WO2012107371A12012-08-16
WO2011071135A12011-06-16
Foreign References:
JP2017071603A2017-04-13
JP2014101354A2014-06-05
US20130072478A12013-03-21
JP2012250933A2012-12-20
Other References:
"Isotopes in the Physical and Biomedical Sciences", vol. 1, 1987, article "Labeled Compounds"
"Design of Prodrugs", 1985, ELSEVIER
"Greene's Protective Group in Organic Synthesis", 2007, JOHN WILY & SONS
J. AM. CHEM. SOC., vol. 82, 1960, pages 5339 - 5342
J. ORG. CHEM., vol. 63, 1998, pages 5272 - 5274
J. AM. CHEM. SOC., vol. 127, 2005, pages 5376 - 5384
"Green's Protective Groups in Organic Synthesis"
CHEM. REV., vol. 111, 2011, pages 6557 - 6602
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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