Title:
TETRAHYDROPYRANYL CYCLOPENTYL BENZYLAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
Document Type and Number:
WIPO Patent Application WO2004041161
Kind Code:
A3
Abstract:
The present invention is directed to compounds of the formula (I) (wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, R<10>, R<11>, R<27>, R<28>, R<29>, R<30>, R<31>, X, m, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
Inventors:
BUTORA GABOR (US)
MILLS SANDER G (US)
PASTERNAK ALEXANDER (US)
SHANKARAN KOTHANDARAMAN (US)
YANG LIHU (US)
ZHOU CHANGYOU (US)
GOBLE STEPHEN D (US)
MILLS SANDER G (US)
PASTERNAK ALEXANDER (US)
SHANKARAN KOTHANDARAMAN (US)
YANG LIHU (US)
ZHOU CHANGYOU (US)
GOBLE STEPHEN D (US)
Application Number:
PCT/US2003/033972
Publication Date:
March 24, 2005
Filing Date:
October 24, 2003
Export Citation:
Assignee:
MERCK & CO INC (US)
BUTORA GABOR (US)
MILLS SANDER G (US)
PASTERNAK ALEXANDER (US)
SHANKARAN KOTHANDARAMAN (US)
YANG LIHU (US)
ZHOU CHANGYOU (US)
GOBLE STEPHEN D (US)
BUTORA GABOR (US)
MILLS SANDER G (US)
PASTERNAK ALEXANDER (US)
SHANKARAN KOTHANDARAMAN (US)
YANG LIHU (US)
ZHOU CHANGYOU (US)
GOBLE STEPHEN D (US)
International Classes:
A61K31/00; C07C237/24; C07D211/58; C07D211/96; C07D305/08; C07D307/22; C07D309/14; C07D311/00; C07D311/02; C07D311/68; C07D311/74; C07D313/04; C07D319/06; C07D333/36; C07D335/02; C07D405/04; C07D405/12; C07D409/12; C07D417/12; C07D491/04; C07D493/08; C07D498/04; (IPC1-7): A61K31/351; C07D257/04; C07D263/48; C07D309/14; C07D491/02
Other References:
SAMSON ET AL.: "Receptor gene", BIOCHEMISTRY, vol. 35, no. 11, 1996, pages 3362 - 3367, XP002035224
See also references of EP 1558243A4
See also references of EP 1558243A4
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